Copper (I)-catalyzed 1, 3-dipolar cycloaddition between organic azides and terminal
alkynes, commonly known as CuAAC or click chemistry, has been identified as one of the …

Cu (I)-catalyzed azide–alkyne 1, 3-dipolar cycloaddition (CuAAC), popularly known as the
“click reaction”, serves as the most potent and highly dependable tool for facile construction …

The gastrointestinal mucus layer is colonized by a dense community of microbes
catabolizing dietary and host carbohydrates during their expansion in the gut. Alterations in …

Human milk oligosaccharides (HMOs), the third major solid component in breast milk, are
recognized as the first prebiotics for health benefits in infants. Sialylated HMOs are an …

Sialic acid, as a component of cell surface glycoconjugates, plays a crucial role in
recognition events. Efficient synthetic methods are necessary for the supply of sialosides in …

Trypanosoma cruzi is the parasite that causes the chronic malady known as Chagas
disease (CD). Only nifurtimox and benznidazole are currently approved to treat CD in acute …

ABSTRACT trans-Sialidase (TS) enzymes catalyze the transfer of sialyl (Sia) residues from
Sia (α2-3) Gal (β1-x)-glycans (sialo-glycans) to Gal (β1-x)-glycans (asialo-glycans). Aiming …

The only drugs approved for the treatment of Chagas disease, nifurtimox and benznidazole,
present toxic side effects and limited efficacy in the chronic stage of the disease, which …

Trypanosomes cause the devastating disease trypanosomiasis, in which the action of trans-
sialidase (TS) enzymes harbored on their surface is a key virulence factor. TS enzymes are …

Cells are covered by a complex array of carbohydrates. Among them, sialosides are of key
importance in intracellular adhesion, recognition and signaling. The need for structurally …