Candida albicans selection for human commensalism results in substantial within-host diversity without decreasing fitness for invasive disease
FM Anderson, ND Visser, KR Amses… - Plos …, 2023 - journals.plos.org
Candida albicans is a frequent colonizer of human mucosal surfaces as well as an
opportunistic pathogen. C. albicans is remarkably versatile in its ability to colonize diverse …
opportunistic pathogen. C. albicans is remarkably versatile in its ability to colonize diverse …
The Candida albicans reference strain SC5314 contains a rare, dominant allele of the transcription factor Rob1 that modulates filamentation, biofilm formation, and …
VE Glazier, J Kramara, T Ollinger, NV Solis… - MBio, 2023 - Am Soc Microbiol
Candida albicans is a diploid human fungal pathogen that displays significant genomic and
phenotypic heterogeneity over a range of virulence traits and in the context of a variety of …
phenotypic heterogeneity over a range of virulence traits and in the context of a variety of …
Bibliometric analysis and thematic review of Candida pathogenesis: Fundamental omics to applications as potential antifungal drugs and vaccines
Invasive candidiasis caused by the pathogenic Candida yeast species has resulted in
elevating global mortality. The pathogenicity of Candida spp. is not only originated from its …
elevating global mortality. The pathogenicity of Candida spp. is not only originated from its …
Molecular association of Candida albicans and vulvovaginal candidiasis: focusing on a solution
H David, AP Solomon - Frontiers in Cellular and Infection …, 2023 - frontiersin.org
Candida albicans-mediated vulvovaginal candidiasis (VVC) is a significant challenge in
clinical settings, owing to the inefficacy of current antifungals in modulating virulence …
clinical settings, owing to the inefficacy of current antifungals in modulating virulence …
Systematic analysis of the Candida albicans kinome reveals environmentally contingent protein kinase-mediated regulation of filamentation and biofilm formation in …
Protein kinases are critical regulatory proteins in both prokaryotes and eukaryotes.
Accordingly, protein kinases represent a common drug target for a wide range of human …
Accordingly, protein kinases represent a common drug target for a wide range of human …
A gain-of-function mutation in zinc cluster transcription factor Rob1 drives Candida albicans adaptive growth in the cystic fibrosis lung environment
M Gnaien, C Maufrais, Y Rebai, A Kallel, L Ma… - PLoS …, 2024 - journals.plos.org
Candida albicans chronically colonizes the respiratory tract of patients with Cystic Fibrosis
(CF). It competes with CF-associated pathogens (eg Pseudomonas aeruginosa) and …
(CF). It competes with CF-associated pathogens (eg Pseudomonas aeruginosa) and …
Bacteria-derived short-chain fatty acids as potential regulators of fungal commensalism and pathogenesis
The human gastrointestinal microbiome encompasses bacteria, fungi, and viruses forming
complex bionetworks which, for organismal health, must be in a state of homeostasis. An …
complex bionetworks which, for organismal health, must be in a state of homeostasis. An …
Eicosapentaenoic acid influences the pathogenesis of Candidaalbicans in Caenorhabditiselegans via inhibition of hyphal formation and stimulation of the host …
NZ Mokoena, H Steyn, A Hugo, T Dix-Peek… - Medical Microbiology …, 2023 - Springer
The intake of omega-3 polyunsaturated fatty acids, including eicosapentaenoic acid (EPA),
is associated with health benefits due to its anti-inflammatory properties. This fatty acid also …
is associated with health benefits due to its anti-inflammatory properties. This fatty acid also …
The role of the C. albicans transcriptional repressor NRG1 during filamentation and disseminated candidiasis is strain dependent
RS Wakade, M Wellington, DJ Krysan - Msphere, 2024 - Am Soc Microbiol
Candida albicans is one of the most common causes of superficial and invasive fungal
diseases in humans. Its ability to cause disease is closely linked to its ability to undergo a …
diseases in humans. Its ability to cause disease is closely linked to its ability to undergo a …
Regulation of candidalysin underlies Candida albicans persistence in intravascular catheters by modulating NETosis
KY Tseng, YT Huang, YT Huang, YT Su… - PLoS …, 2024 - journals.plos.org
Candida albicans is a leading cause of intravascular catheter-related infections. The
capacity for biofilm formation has been proposed to contribute to the persistence of this …
capacity for biofilm formation has been proposed to contribute to the persistence of this …