Aptamers are single-stranded DNA or RNA oligonucleotides that can selectively bind to a
specific target. They are generally obtained by SELEX, but the procedure is challenging and …

Aptamers are short nucleic acid sequences capable of specific, high-affinity molecular
binding. They are isolated via SELEX (Systematic Evolution of Ligands by Exponential …

Abstract Web 3DNA (w3DNA) 2.0 is a significantly enhanced version of the widely used
w3DNA server for the analysis, visualization, and modeling of 3D nucleic-acid-containing …

Small‐angle scattering (SAS) of X‐rays and neutrons is a fundamental tool to study the
nanostructural properties, and in particular, biological macromolecules in solution. In …

Computational docking is the prediction or modeling of the three-dimensional structure of a
biomolecular complex, starting from the structures of the individual molecules in their free …

Epigenetic regulation is mediated by protein complexes that couple recognition of chromatin
marks to activity or recruitment of chromatin-modifying enzymes. Polycomb repressive …

Chromatin-remodelling complexes of the SWI/SNF family function in the formation of
nucleosome-depleted, transcriptionally active promoter regions (NDRs),. In the yeast …

The general transcription factor IID (TFIID) plays a central role in the initiation of RNA
polymerase II (Pol II)-dependent transcription by nucleating pre-initiation complex (PIC) …

In eukaryotes, DNA polymerase δ (Pol δ) bound to the proliferating cell nuclear antigen
(PCNA) replicates the lagging strand and cooperates with flap endonuclease 1 (FEN1) to …

Eukaryotic transcription initiation requires the assembly of general transcription factors into a
pre-initiation complex that ensures the accurate loading of RNA polymerase II (Pol II) at the …