Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation

M Chehelgerdi, M Chehelgerdi, OQB Allela… - Molecular cancer, 2023 - Springer
The use of nanotechnology has the potential to revolutionize the detection and treatment of
cancer. Developments in protein engineering and materials science have led to the …

Applications of various types of nanomaterials for the treatment of neurological disorders

A Waris, A Ali, AU Khan, M Asim, D Zamel, K Fatima… - Nanomaterials, 2022 - mdpi.com
Neurological disorders (NDs) are recognized as one of the major health concerns globally.
According to the World Health Organization (WHO), neurological disorders are one of the …

Ultrasound trapping and navigation of microrobots in the mouse brain vasculature

A Del Campo Fonseca, C Glück, J Droux… - Nature …, 2023 - nature.com
The intricate and delicate anatomy of the brain poses significant challenges for the treatment
of cerebrovascular and neurodegenerative diseases. Thus, precise local drug delivery in …

ROS-responsive 18β-glycyrrhetic acid-conjugated polymeric nanoparticles mediate neuroprotection in ischemic stroke through HMGB1 inhibition and microglia …

L Jin, Z Zhu, L Hong, Z Qian, F Wang, Z Mao - Bioactive materials, 2023 - Elsevier
Ischemic stroke is an acute and serious cerebral vascular disease, which greatly affects
people's health and brings huge economic burden to society. Microglia, as important innate …

Customizing delivery nano-vehicles for precise brain tumor therapy

YB Miao, W Zhao, G Renchi, Y Gong, Y Shi - Journal of …, 2023 - Springer
Although some tumor has become a curable disease for many patients, involvement of the
central nervous system (CNS) is still a major concern. The blood–brain barrier (BBB), a …

Advanced nano drug delivery systems for neuroprotection against ischemic stroke

C Xie, J Liao, N Zhang, Y Sun, Y Li, L Xiong… - Chinese Chemical …, 2024 - Elsevier
Ischemic stroke (IS) represents a significant threat to brain health due to its elevated
mortality and disability rates. The efficacy of small-molecule neuroprotective agents has …

[HTML][HTML] C-176 loaded Ce DNase nanoparticles synergistically inhibit the cGAS-STING pathway for ischemic stroke treatment

Z Zhu, H Lu, L Jin, Y Gao, Z Qian, P Lu, W Tong, PK Lo… - Bioactive Materials, 2023 - Elsevier
The neuroinflammatory responses following ischemic stroke cause irreversible nerve cell
death. Cell free-double strand DNA (dsDNA) segments from ischemic tissue debris are …

Reactive oxygen species-responsive transformable and triple-targeting butylphthalide nanotherapy for precision treatment of ischemic stroke by normalizing the …

Q Yang, W Pu, K Hu, Y Hu, Z Feng, J Cai, C Li, L Li… - ACS …, 2023 - ACS Publications
High potency and safe therapies are still required for ischemic stroke, which is a leading
cause of global death and disability. Herein, a reactive oxygen species (ROS)-responsive …

Targeted pathophysiological treatment of ischemic stroke using nanoparticle-based drug delivery system

W Liu, L Liu, H Li, Y Xie, J Bai, J Guan, H Qi… - Journal of …, 2024 - Springer
Ischemic stroke poses significant challenges in terms of mortality and disability rates
globally. A key obstacle to the successful treatment of ischemic stroke lies in the limited …

Ultrasound‐controlled Swarmbots under physiological flow conditions

ADC Fonseca, T Kohler… - Advanced Materials …, 2022 - Wiley Online Library
Navigation of microrobots in living vasculatures is essential in realizing targeted drug
delivery and advancing non‐invasive surgeries. Acoustically‐controlled “swarmbots” are …