Inevitable byproducts of aerobic metabolism are free radicals and other highly reactive
oxidants and nitrosants that are continuously formed within cells. Most cells generally …

Covalent amino acid modification significantly expands protein functional capability in
regulating biological processes. Tyrosine residues can undergo phosphorylation, sulfation …

LRRK2 is a kinase mutated in Parkinson's disease, but how the protein affects synaptic
function remains enigmatic. We identified LRRK2 as a critical regulator of EndophilinA …

Under resting conditions, Pink1 knockout cells and cells derived from patients with PINK1
mutations display a loss of mitochondrial complex I reductive activity, causing a decrease in …

Nitrotyrosine is one of the post-translational modifications (PTMs) in proteins that occurs
when their tyrosine residue is nitrated. Compared with healthy people, a remarkably …

Mutations in the gene encoding Parkin are a major cause of recessive Parkinson's disease.
Recent work has shown that Parkin translocates from the cytosol to depolarized …

Revised and updated, Chemical Reagents for Protein Modification, Third Edition is an
encyclopedic work describing the many approaches to the site-specific modification of …

The ultimate goal of proteomics is determination of the exact chemical composition of protein
species, including their complete amino acid sequence and the identification of each …

N-terminal acetylation (N-Ac) is a highly abundant eukaryotic protein modification.
Proteomics revealed a significant increase in the occurrence of N-Ac from lower to higher …

Nitration of tyrosine (Y) residues of proteins is a low abundant post-translational modification
that modulates protein function or fate in animal systems. However, very little is known about …