Vascular smooth muscle cells (VSMCs) are involved in phenotypic switching in
atherosclerosis. This switching is characterized by VSMC dedifferentiation, migration, and …

Atherosclerosis is a chronic inflammatory disease that involves the accumulation of lipids
and immune cells in the arterial wall. NF-kB signaling is a key regulator of inflammation and …

Background: Vascular homeostasis is maintained by the differentiated phenotype of
vascular smooth muscle cells (VSMCs). The landscape of protein coding genes comprising …

Age-related changes to the genome-wide DNA methylation (DNAm) pattern observed in
blood are well-documented. Clonal hematopoiesis of indeterminate potential (CHIP) …

Atherosclerosis, the principal cause of cardiovascular death worldwide, is a pathological
disease characterized by fibro-proliferation, chronic inflammation, lipid accumulation, and …

Paraspeckles are nuclear condensates, or membranelees organelles, that are built on the
long noncoding RNA, NEAT1, and have been linked to many diseases. Although originally …

NEAT1 is a highly abundant nuclear architectural long non-coding RNA. There are two
overlapping NEAT1 isoforms, NEAT1_1 and NEAT1_2, of which the latter is an essential …

Cardiac remodeling is a self‐regulatory response of the myocardium and vasculature under
the stressful condition. Cardiomyocytes (CMs), vascular smooth muscle cells (VSMCs) …

Alterations in the vascular smooth muscle cells (VSMC) phenotype play a critical role in the
pathogenesis of several cardiovascular diseases, including hypertension, atherosclerosis …

Neat1 is widely expressed in many tissues and cells and exerts pro-proliferation effects on
many cancer cells. However, little is known about the function of Neat1 in myogenesis. Here …