The ERCC1–XPF complex is a structure-specific endonuclease essential for the repair of
DNA damage by the nucleotide excision repair pathway. It is also involved in other key …

The ERCC1 and ERCC4 genes encode the two subunits of the ERCC1–XPF nuclease. This
enzyme plays an important role in repair of DNA damage and in maintaining genomic …

Fanconi anemia (FA) is a recessive genetic disorder caused by biallelic mutations in at least
one of 22 FA genes. Beyond its pathological presentation of bone marrow failure and …

Numerous proteins are involved in the multiple pathways of the DNA damage response
network and play a key role to protect the genome from the wide variety of damages that can …

Nucleotide excision repair (NER) is a multistep process that recognizes and eliminates a
wide spectrum of damage causing significant distortions in the DNA structure, such as UV …

Nucleotide excision repair (NER) removes helix-distorting DNA lesions and is therefore
critical for genome stability. During NER, DNA is unwound on either side of the lesion and …

Modifications in DNA repair pathways are recognized as prognostic markers and potential
therapeutic targets in various cancers, including non-small cell lung cancer (NSCLC) …

The xeroderma pigmentosum complementation group proteins (XPs), which include XPA
through XPG, play a critical role in coordinating and promoting global genome and …

Lack of structure is often an essential functional feature of protein domains. The coordination
of macromolecular assemblies in DNA repair pathways is yet another task disordered …

In eukaryotic meiosis, generation of haploid gametes depends on the formation of inter-
homolog crossovers, which enable the pairing, physical linkage, and eventual segregation …