Objective: Oxygen is vital during critical illness, but hyperoxia may harm patients. Our aim
was to systematically evaluate the methodology and findings of cohort studies investigating …

The immature brain has long been considered to be resistant to the damaging effects of
hypoxia and hypoxia–ischemia (H/I). However, it is now appreciated that there are specific …

Background Guidelines recommend normocapnia for adults with coma who are resuscitated
after out-of-hospital cardiac arrest. However, mild hypercapnia increases cerebral blood flow …

Perinatal cerebral hypoxia–ischemia remains a frequent cause of the chronic handicapping
conditions of cerebral palsy, mental retardation, learning disability, and epilepsy. 1 …

Brain injury secondary to hypoxic‐ischemic disease is the predominant form of all brain
injury encountered in the perinatal period. The focus of this article is the most recent …

Early research in the Vannucci laboratory prior to 1981 focused largely on brain energy
metabolism in the developing rat. At that time, there was no experimental model to study the …

To gain insights into the pathogenesis and management of perinatal hypoxic‐ischemic brain
damage, the authors have used an immature rat model which they developed many years …

Objectives: Hypocapnia is used in the management of acute brain injury and may be life-
saving in specific circumstances, but it can produce neuronal ischemia and injury, potentially …

Background—Partial pressure of arterial CO2 (Paco2) is a regulator of cerebral blood flow
after brain injury. Recent guidelines for the management of cardiac arrest recommend …

Neurologic complications after cardiac surgery are of growing importance for an aging
surgical population. In this review, we provide a critical appraisal of the impact of current …