Chalcones (1, 3-diaryl-2-propen-1-ones) are precursors for flavonoids and isoflavonoids,
which are common simple chemical scaffolds found in many naturally occurring compounds …

Increasing evidence has been reported regarding phytochemicals, plant secondary
metabolites, having therapeutic functions against numerous human diseases. Recently …

Acute cadmium (Cd) exposure is a significant risk factor for renal injury and lacks effective
treatment strategies. Ferroptosis is a recently identified iron-dependent form of nonapoptotic …

Glioblastoma multiforme (GBM) is a common malignancy of the central nervous system, but
conventional treatments yield unsatisfactory results. Although innovative therapeutic …

Autophagy, which is a conserved biological process and essential mechanism in
maintaining homeostasis and metabolic balance, enables cells to degrade cytoplasmic …

Glioma is the most frequent and aggressive type of brain neoplasm, being anaplastic
astrocytoma (AA) and glioblastoma multiforme (GBM), its most malignant forms. The survival …

External and internal stimuli are often involved in the pathogenesis of tumors, and the
deterioration of endoplasmic reticulum (ER) function within cells is also an important …

Gastrointestinal (GI) cancers with a high incidence rate and adverse complications are
associated with severe morbidity and mortality around the world. It is well recognized that …

Endoplasmic reticulum (ER) stress has considerable impact on cell growth, proliferation,
metastasis, invasion, angiogenesis and chemoradiotherapy resistance in various cancers …

Cancer is one of the most serious diseases endangering human health. In view of the side
effects caused by chemotherapy and radiotherapy, it is necessary to develop low-toxic anti …