Living organisms are continuously exposed to a myriad of DNA damaging agents that can
impact health and modulate disease‐states. However, robust DNA repair and damage …

The Myc proto-oncogene family consists of three members, C-MYC, MYCN, and MYCL,
which encodes the transcription factor c-Myc (hereafter Myc), N-Myc, and L-Myc …

The emergence of drug resistance limits the efficacy of targeted therapies in human tumors.
The prevalent view is that resistance is a fait accompli: when treatment is initiated, cancers …

Areas of hypoxic tumour tissue are known to be resistant to treatment and are associated
with a poor clinical prognosis. There are several reasons why this might be, including the …

Chromosome structural changes with nonrecurrent endpoints associated with genomic
disorders offer windows into the mechanism of origin of copy number variation (CNV). A …

Hypoxia, a common feature of solid tumors, greatly hinders the efficacy of conventional
cancer treatments such as chemo-, radio-, and immunotherapy. The depletion of oxygen in …

Our concept of a stable genome is evolving to one in which genomes are plastic and
responsive to environmental changes. Growing evidence shows that a variety of …

Somatic hypermutation introduces point mutations into immunoglobulin genes in germinal
centre B cells during an immune response. The reaction is initiated by cytosine deamination …

Inadequate oxygen availability or hypoxia induces a complex and still incompletely
understood set of adaptations that influence cellular survival and function. Many of these …

Genetic instability is a hallmark of cancer; the hypoxic tumor microenvironment has been
implicated as a cause of this phenomenon. MicroRNAs (miR) are small nonprotein coding …