Telomerase is an attractive cancer target as it appears to be required in essentially all
tumours for immortalization of a subset of cells, including cancer stem cells. Moreover …

Telomeres are protective caps at the ends of human chromosomes. Telomeres shorten with
each successive cell division in normal human cells whereas, in tumors, they are …

One of the hallmarks of advanced malignancies is continuous cell growth and this almost
universally correlates with the reactivation of telomerase. Although there is still much we do …

Telomerase activity is dependent on the expression of 2 main core component genes,
hTERT, which encodes the catalytic component and hTR (also called TERC), which …

Telomerase is a reverse transcriptase capable of utilizing an integrated RNA component as
a template to add protective tandem telomeric single strand DNA repeats, TTAGGG, to the …

Colorectal cancer (CRC) is the second most common type of malignancy in Western nations.
Improvements in surgical and radiotherapeutic techniques and the increased availability of …

The systemic delivery of genetic therapies required for the treatment of inaccessible tumors
and metastases remains a challenge despite the development of various viral and synthetic …

One of the hallmarks of malignant cell populations is the ability to undergo continuous
proliferation. This property allows clonal lineages to acquire sequential aberrations that can …

In most human cancers, the telomere erosion problem has been bypassed through the
activation of a telomere maintenance system (usually activation of telomerase). Therefore …

Basal telomerase activity is dependent on expression of the hTERT and hTR genes and
upregulation of telomerase gene expression is associated with tumour development. It is …