Bringing synapses into focus: Recent advances in synaptic imaging and mass-spectrometry for studying synaptopathy

N Hindley, A Sanchez Avila… - Frontiers in Synaptic …, 2023 - frontiersin.org
Synapses are integral for healthy brain function and are becoming increasingly recognized
as key structures in the early stages of brain disease. Understanding the pathological …

Decoding transcriptomic signatures of cysteine string protein alpha–mediated synapse maintenance

N Wang, B Zhu, MA Allnutt… - Proceedings of the …, 2024 - National Acad Sciences
Synapse maintenance is essential for generating functional circuitry, and decrement in this
process is a hallmark of neurodegenerative disease. Yet, little is known about synapse …

On human nanoscale synaptome: Morphology modeling and storage estimation

WL Nowinski - Plos one, 2024 - journals.plos.org
One of the key challenges in neuroscience is to generate the human nanoscale connectome
which requires comprehensive knowledge of synaptome forming the neural microcircuits …

Cysteine String Protein alpha in Extracellular Vesicle Subtypes: a Proteomic Analysis

LG Nogueira de Almeida, V Armstrong, A Dufour… - bioRxiv, 2023 - biorxiv.org
Cysteine string protein (CSPα/DnaJC5) is a presynaptic J-domain protein (JDP) that
prevents neurodegeneration. CSPα/DnaJC5 is reported to facilitate export of distinct, highly …

[HTML][HTML] Diagnostic Accuracy of Combined Measurement of Serum Homocysteine, C-Reactive Protein, and Serum Ferritin in Mild Cognitive Impairments and …

Y Li, L Duan, Y Shi, J Qi, T Li - Journal of the College of Physicians and …, 2024 - jcpsp.pk
Objective: Evaluation of the diagnostic accuracy of combined detection of serum
homocysteine (Hcy), C-reactive protein (CRP), and serum ferritin (SF) levels in patients with …