The discovery of leptin was intrinsically associated with its ability to regulate body weight.
However, the effects of leptin are more far-reaching and include profound glucose-lowering …

Phosphoinositide 3-kinase (PI3K) signaling contributes to a variety of processes, mediating
many aspects of cellular function, including nutrient uptake, anabolic reactions, cell growth …

The ventromedial nucleus of the hypothalamus (VMH) is a complex brain structure that is
integral to many neuroendocrine functions, including glucose regulation, thermogenesis …

The neuroendocrine hypothalamus is the central regulator of vital physiological homeostasis
and behavior. However, the cellular and molecular properties of hypothalamic neural …

The ventromedial hypothalamus (VMH) regulates glucose and energy metabolism in
mammals. Optogenetic stimulation of VMH neurons that express steroidogenic factor 1 (SF1) …

The ventromedial hypothalamic nucleus (VMH) regulates glucose production in the liver as
well as glucose uptake and utilization in peripheral tissues, including skeletal muscle and …

It is well known that the neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons
increase appetite and decrease thermogenesis. Previous studies demonstrated that …

Despite the substantial role played by the hypothalamus in the regulation of energy balance
and glucose homeostasis, the exact mechanisms and neuronal circuits underlying this …

The ventromedial hypothalamus (VMH) plays chief roles regulating energy and glucose
homeostasis and is sexually dimorphic. We discovered that expression of metabotropic …

Atypical antipsychotics such as risperidone cause drug-induced metabolic syndrome.
However, the underlying mechanisms remain largely unknown. Here, we report a new …