Waardenburg syndrome (WS) is characterized by the association of pigmentation
abnormalities, including depigmented patches of the skin and hair, vivid blue eyes or …

SOX10 belongs to a family of 20 SRY (sex-determining region Y)-related high mobility group
box-containing (SOX) proteins, most of which contribute to cell type specification and …

Technological innovation has helped the zebrafish embryo gain ground as a disease model
and an assay system for drug screening. Here, we review the use of zebrafish embryos and …

The in vivo mechanisms underlying dominant syndromes caused by mutations in SRY-Box
Transcription Factor 9 (SOX9) and SOX10 (SOXE) transcription factors, when they either are …

BACKGROUND AND PURPOSE: Waardenburg syndrome, characterized by deafness and
pigmentation abnormalities, is clinically and genetically heterogeneous, consisting of 4 …

Teleost fish such as zebrafish (Danio rerio) are increasingly used for physiological, genetic
and developmental studies. Our understanding of the physiological consequences of altered …

The inner ear and cochleovestibular ganglion (CVG) derive from a specialized region of
head ectoderm termed the otic placode. During embryogenesis, the otic placode invaginates …

Forward genetic screens in zebrafish have identified> 9000 mutants, many of which are
potential disease models. Most mutants remain molecularly uncharacterized because of the …

The vertebrate inner ear is a precision sensory organ, acting as both a microphone to
receive sound and an accelerometer to detect gravity and motion. It consists of a series of …

Morphogenesis of the semicircular canal ducts in the vertebrate inner ear is a dramatic
example of epithelial remodelling in the embryo, and failure of normal canal development …