Immunomodulatory effects of dopamine in inflammatory diseases

Y Feng, Y Lu - Frontiers in immunology, 2021 - frontiersin.org
Dopamine (DA) receptor, a significant G protein-coupled receptor, is classified into two
families: D1-like (D1 and D5) and D2-like (D2, D3, and D4) receptor families, with further …

The endocannabinoid system as a target in cancer diseases: are we there yet?

E Moreno, M Cavic, A Krivokuca, V Casadó… - Frontiers in …, 2019 - frontiersin.org
The endocannabinoid system (ECS) has been placed in the anti-cancer spotlight in the last
decade. The immense data load published on its dual role in both tumorigenesis and …

Exosomes from astrocyte processes: signaling to neurons

A Venturini, M Passalacqua, S Pelassa… - Frontiers in …, 2019 - frontiersin.org
It is widely recognized that extracellular vesicles subserve non-classical signal transmission
in the central nervous system. Here we assess if the astrocyte processes, that are …

Tyrosinase-Based Proximity Labeling in Living Cells and In Vivo

H Zhu, JH Oh, Y Matsuda, T Mino… - Journal of the …, 2024 - ACS Publications
Characterizing the protein constituents of a specific organelle and protein neighbors of a
protein of interest (POI) is essential for understanding the function and state of the organelle …

Astrocyte-neuron signaling in the mesolimbic dopamine system: the hidden stars of dopamine signaling

M Corkrum, A Araque - Neuropsychopharmacology, 2021 - nature.com
Astrocytes are fundamental components of brain information processing and possess the
ability to respond to synaptic signaling with increases in cytoplasmic calcium and modulate …

[HTML][HTML] The dopamine system: insights between kidney and brain

A de Donato, V Buonincontri, G Borriello… - Kidney and Blood …, 2022 - karger.com
Background: Chronic kidney disease (CKD) is one of the most common diseases in adult
age, and it is typical of older adults. Recent data suggest that almost half of the elders have …

[HTML][HTML] Receptor-receptor interactions and microvesicle exchange as mechanisms modulating signaling between neurons and astrocytes

D Guidolin, C Tortorella, M Marcoli, C Cervetto… - …, 2023 - Elsevier
It is well known that astrocytes play a significant metabolic role in the nervous tissue,
maintaining the homeostasis of the extracellular space and of the blood-brain barrier, and …

Receptor-receptor interactions as a widespread phenomenon: novel targets for drug development?

D Guidolin, M Marcoli, C Tortorella, G Maura… - Frontiers in …, 2019 - frontiersin.org
The discovery of receptor-receptor interactions (RRI) has expanded our understanding of
the role that G protein-coupled receptors (GPCRs) play in intercellular communication. The …

[HTML][HTML] Striatal astrocytic A2A-D2 receptor-receptor interactions and their role in neuropsychiatric disorders

C Cervetto, G Maura, D Guidolin, S Amato, C Ceccoli… - …, 2023 - Elsevier
It is now generally accepted that astrocytes are active players in synaptic transmission, so
that a neurocentric perspective of the integrative signal communication in the central …

Heteromerization of dopamine D2 and oxytocin receptor in adult striatal astrocytes

S Amato, M Averna, D Guidolin, C Ceccoli… - International Journal of …, 2023 - mdpi.com
The ability of oxytocin (OT) to interact with the dopaminergic system through facilitatory D2-
OT receptor (OTR) receptor-receptor interaction in the limbic system is increasingly …