The role of the CXCL12/CXCR4/CXCR7 chemokine axis in cancer
Chemokines are a family of small, secreted cytokines which regulate a variety of cell
functions. The CXC motif chemokine ligand 12 (CXCL12) binds to CXC chemokine receptor …
functions. The CXC motif chemokine ligand 12 (CXCL12) binds to CXC chemokine receptor …
Targeting glucose metabolism enzymes in cancer treatment: current and emerging strategies
Simple Summary Reprogramming of glucose metabolism is a hallmark of cancer and can be
targeted by therapeutic agents. Some metabolism regulators, such as ivosidenib and …
targeted by therapeutic agents. Some metabolism regulators, such as ivosidenib and …
[PDF][PDF] Acetylation of PGK1 promotes liver cancer cell proliferation and tumorigenesis
Phosphoglycerate kinase 1 (PGK1) is an important enzyme in the metabolic glycolysis
pathway. In this study, we observed a significant overexpression of PGK1 in liver cancer …
pathway. In this study, we observed a significant overexpression of PGK1 in liver cancer …
Targeting KRAS Mutant Non-Small-Cell Lung Cancer: Past, Present and Future
IZ Uras, HP Moll, E Casanova - International Journal of Molecular …, 2020 - mdpi.com
Lung cancer is the most frequent cancer with an aggressive clinical course and high
mortality rates. Most cases are diagnosed at advanced stages when treatment options are …
mortality rates. Most cases are diagnosed at advanced stages when treatment options are …
Altered regulation of metabolic pathways in human lung cancer discerned by 13C stable isotope-resolved metabolomics (SIRM)
Background Metabolic perturbations arising from malignant transformation have not been
systematically characterized in human lung cancers in situ. Stable isotope resolved …
systematically characterized in human lung cancers in situ. Stable isotope resolved …
Roles of p53, MYC and HIF-1 in regulating glycolysis—the seventh hallmark of cancer
SJ Yeung, J Pan, MH Lee - Cellular and molecular life sciences, 2008 - Springer
Despite diversity in genetic events in oncogenesis, cancer cells exhibit a common set of
functional characteristics. Otto Warburg discovered that cancer cells have consistently …
functional characteristics. Otto Warburg discovered that cancer cells have consistently …
Human body fluid proteome analysis
The focus of this article is to review the recent advances in proteome analysis of human
body fluids, including plasma/serum, urine, cerebrospinal fluid, saliva, bronchoalveolar …
body fluids, including plasma/serum, urine, cerebrospinal fluid, saliva, bronchoalveolar …
[HTML][HTML] PGK1-mediated cancer progression and drug resistance
Y He, Y Luo, D Zhang, X Wang, P Zhang… - American journal of …, 2019 - ncbi.nlm.nih.gov
Abstract Phosphoglycerate kinase 1 (PGK1) is an essential enzyme in the aerobic glycolysis
pathway. PGK1 catalyzes the reversible transfer of a phosphate group from 1, 3 …
pathway. PGK1 catalyzes the reversible transfer of a phosphate group from 1, 3 …
FOXO3A-induced LINC00926 suppresses breast tumor growth and metastasis through inhibition of PGK1-mediated Warburg effect
Z Chu, N Huo, X Zhu, H Liu, R Cong, L Ma, X Kang… - Molecular Therapy, 2021 - cell.com
Phosphoglycerate kinase 1 (PGK1), a critical component of the glycolytic pathway, relates to
the development of various cancers. However, the mechanisms of PGK1 inhibition and …
the development of various cancers. However, the mechanisms of PGK1 inhibition and …
Joint analysis of two microarray gene-expression data sets to select lung adenocarcinoma marker genes
Background Due to the high cost and low reproducibility of many microarray experiments, it
is not surprising to find a limited number of patient samples in each study, and very few …
is not surprising to find a limited number of patient samples in each study, and very few …