Heparin has been used extensively as an antithrombotic and anticoagulant for close to 100
years. This anticoagulant activity is attributed mainly to the pentasaccharide sequence …

Polysaccharides are ubiquitous biomolecules found in nature that contain various biological
and pharmacological activities that are employed in functional foods and therapeutic agents …

Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has resulted in a
pandemic and continues to spread around the globe at an unprecedented rate. To date, no …

1372 Heparin and anticoagulation Akihiro Onishi1, Kalib St Ange1, Jonathan S. Dordick1, Robert
J. Linhardt1 1Center for Biotechn Page 1 1372 [Frontiers in Bioscience, Landmark, 21 …

Heparan sulfate (HS) polysaccharides are master regulators of diverse biological processes
via sulfated motifs that can recruit specific proteins. 3-O-sulfation of HS/heparin is crucial for …

Highlights•Metabolic engineering of heparosan, heparin and heparan sulfate•Chemical and
chemoenzymatic synthesis of low molecular weight heparins•Development of new heparin …

Chondroitin sulfates, widely used in the treatment of arthritis, are glycosaminoglycans
extracted from food animal tissues. As part of our ongoing efforts to separate the food chain …

The purification of heparin from offal is an old industrial process for which commercial
recipes date back to 1922. Although chemical, chemoenzymatic, and biotechnological …

Heparin and heparan sulfates are closely related linear anionic polysaccharides, called
glycosaminoglycans, which exhibit a number of important biological and pharmacological …

Heparin is a life-saving drug, which belongs to few clinically used drugs without defined
molecular structures in modern medicine. Heparin is the mostly negatively charged …