Among the four proteolytic systems in the cell, autophagy and the ubiquitin-proteasome
system (UPS) are the main proteolytic events that allow for the removal of cell debris and …

The double-stranded multifunctional RNA-binding protein (dsRBP) Staufen was initially
discovered in insects as a regulator of mRNA localization. Later, its mammalian orthologs …

Abstract Myotonic dystrophy type 1 (DM1) is a debilitating multisystemic disorder caused by
a triplet repeat expansion in the 3'untranslated region of dystrophia myotonica protein …

Gene expression in a tissue-specific context depends on the combined efforts of epigenetic,
transcriptional and post-transcriptional processes that lead to the production of specific …

Cellular stress has been considered a relevant pathogenetic factor in a variety of human
diseases. Due to its primary functions by means of contractility, metabolism, and protein …

The nucleocapsid (NC) is an N-terminal protein derived from the HIV-1 Gag precursor
polyprotein, pr55Gag. NC possesses key functions at several pivotal stages of viral …

Stau1 is a pluripotent RNA-binding protein that is responsible for the post-transcriptional
regulation of a multitude of transcripts. Here, we observed that lung cancer patients with a …

Animals require different types of muscle for survival, for example for circulation, motility,
reproduction and digestion. Much emphasis in the muscle field has been placed on …

Abstract Myotonic Dystrophy type 1 (DM1) is caused by an expansion of CUG repeats in
DMPK mRNAs. This mutation affects alternative splicing through misregulation of RNA …

In recent years, an increasing number of reports have linked the RNA‐binding protein
Staufen1 (STAU1) to the control of cell decision making. In non‐transformed cells, STAU1 …