New avenues for phosphodiesterase inhibitors in asthma

MG Matera, J Ora, F Cavalli, P Rogliani… - Journal of …, 2021 - Taylor & Francis
Introduction Phosphodiesterases (PDEs) are isoenzymes ubiquitously expressed in the
lungs where they catalyse cyclic adenosine monophosphate (cAMP) and cyclic guanosine …

Cross talk between Hsp72, HMGB1 and RAGE/ERK1/2 signaling in the pathogenesis of bronchial asthma in obese patients

NA Soliman, MT Abdel Ghafar, RM El Kolaley… - Molecular Biology …, 2020 - Springer
Background The incidence of obesity-related asthma has shown a remarkable increase.
Objectives We aimed to explore the role of heat shock protein 72 (Hsp72) and receptor for …

Evaluation of the effectiveness of Tadalafil on improving pulmonary function and asthma severity in severe asthmatic patients: a randomized controlled trial study

SH Borsi, SAAFM Fakhr, MD Mal-Amir… - … Archives for Chest …, 2025 - monaldi-archives.org
Phosphodiesterase inhibitors elevate the levels of cyclic adenosine monophosphate and
cyclic guanosine monophosphate, which have been associated with various anti …

[HTML][HTML] Oxidative Stress: Assessment of Thiobarbituric Acid Reactive Substances Value in Overweight Asthmatic Children

SA Mansour, MAMH Essa… - Biomedical and …, 2022 - biomedpharmajournal.org
Nowadays bronchial asthma and increased body weight represent major problems in
children. Asthmatic attacks in obese patients are not well controlled using the conventional …