Positron emission tomography with selective radioligands advances the drug discovery and
development process by revealing information about target engagement, proof of …

Sigma receptors (sigma-1 and sigma-2) represent two independent classes of proteins.
Their endogenous ligands may include the hallucinogen N, N-dimethyltryptamine (DMT) …

The vascular interface of the brain, known as the blood–brain barrier (BBB), is understood to
maintain brain function in part via its low transcellular permeability,–. Yet, recent studies …

Ageing drives changes in neuronal and cognitive function, the decline of which is a major
feature of many neurological disorders. The hippocampus, a brain region subserving roles …

The dopamine transporter (DAT) regulates dopamine (DA) neurotransmission by
recapturing DA into the presynaptic terminals and is a principal target of the psychostimulant …

Glioblastoma multiforme (GBM) is the deadliest type of brain tumor, affecting approximately
three in 100,000 adults annually. Positron emission tomography (PET) imaging provides an …

The sigma-2 receptor has been cloned and identified as Tmem97, which is a
transmembrane protein involved in intracellular Ca 2+ regulation and cholesterol …

Abstract Sigma-1 receptor (Sig-1R) is a protein present in several organs such as brain,
lung, and heart. In a cell, Sig-1R is mainly located across the membranes of the …

Microglial activation is a key pathological feature of Alzheimer's disease (AD). PET imaging
of translocator protein 18 kDa (TSPO) is a strategy to detect microglial activation in vivo …

The ability to locate nerve injury and ensuing neuroinflammation would have tremendous
clinical value for improving both the diagnosis and subsequent management of patients …