Alterations in energy metabolism are associated with depression. However, the role of
glycolysis in the pathogenesis of depression and the underlying molecular mechanisms …

Adult neural plasticity engages mechanisms that change synapse structure and function, yet
many of the underlying events bear a striking similarity to processes that occur during the …

Depression is a severe neuropsychiatric disorder, of which the underlying pathological
mechanisms remain unclear. The ketogenic diet (KD) has been reported to exhibit …

Chronic pain can cause both hyperalgesia and anxiety symptoms. However, how the two
components are encoded in the brain remains unclear. The prelimbic cortex (PrL), a critical …

Five decades ago, long-term potentiation (LTP) of synaptic transmission was discovered at
entorhinal cortex→ dentate gyrus (EC→ DG) synapses, but the molecular determinants of …

Structural plasticity, the ability of dendritic spines to change their volume in response to
synaptic stimulation, is an essential determinant of synaptic strength and long-term …

Immune response plays a crucial role in post-myocardial infarction (MI) myocardial
remodeling. Neogenin (Neo1), a multifunctional transmembrane receptor, plays a critical …

Fear learning and memory are crucial for animal survival. Abnormal fear memory is a
hallmark of many neuropsychiatric disorders. Appropriate neuronal activation and …

Epilepsy, a common neurological disorder, is featured with recurrent seizures. Its underlying
pathological mechanisms remain elusive. Here, we provide evidence for loss of neogenin …

Acute traumatic event exposure is a direct cause of post-traumatic stress disorder (PTSD).
Amygdala is suggested to be associated with the development of PTSD. In our previous …