Immunotherapy of brain metastases: breaking a “dogma”

AM Di Giacomo, M Valente, A Cerase… - Journal of Experimental …, 2019 - Springer
Until very few years ago, the oncology community dogmatically excluded any clinical
potential for immunotherapy in controlling brain metastases. Therefore, despite the …

Risk of brain metastases in patients with nonmetastatic lung cancer: Analysis of the Metropolitan Detroit Surveillance, Epidemiology, and End Results (SEER) data

PH Goncalves, SL Peterson, FD Vigneau, RD Shore… - Cancer, 2016 - Wiley Online Library
BACKGROUND Brain metastases (BM) remain an important cause of morbidity and mortality
in patients with lung cancer. The current study evaluated population‐based incidence and …

[HTML][HTML] Brain metastases in ALK-positive NSCLC–time to adjust current treatment algorithms

F Griesinger, J Roeper, C Pöttgen, KC Willborn… - Oncotarget, 2018 - ncbi.nlm.nih.gov
The progress in molecular biology has revolutionized systemic treatment of advanced non-
small-cell lung cancer (NSCLC) from conventional chemotherapy to a treatment stratified by …

A systematic review of brain metastases from lung cancer using magnetic resonance neuroimaging: Clinical and technical aspects

S Ghaderi, S Mohammadi… - Journal of Medical …, 2024 - Wiley Online Library
Abstract Introduction Brain metastases (BMs) are common in lung cancer (LC) and are
associated with poor prognosis. Magnetic resonance imaging (MRI) plays a vital role in the …

Discordance of mutation statuses of epidermal growth factor receptor and K-ras between primary adenocarcinoma of lung and brain metastasis

KM Rau, HK Chen, LY Shiu, TL Chao, YP Lo… - International Journal of …, 2016 - mdpi.com
Mutations on epidermal growth factor receptor (EGFR) of adenocarcinomas of lung have
been found to be associated with increased sensitivity to EGFR tyrosine kinase inhibitors …

Brain imaging in lung cancer staging: A real-world, multi-centre study of prevalence of brain metastases, impact on treatment and re-modelling of the NICE health …

C Brockelsby, R Maconachie, N Navani, R Prendecki… - Lung Cancer, 2023 - Elsevier
Abstract Introduction In 2019, the National Institute for Health and Care Excellence (NICE)
updated their recommendations with respect to brain imaging in the staging of non-small cell …

Lymph node size predicts for asymptomatic brain metastases in patients with non–small-cell lung cancer at diagnosis

SR Rice, JK Molitoris, MAL Vyfhuis, MJ Edelman… - Clinical lung cancer, 2019 - Elsevier
Background We questioned whether the National Comprehensive Cancer Network
recommendations for brain magnetic resonance imaging (MRI) for patients with stage≥ IB …

[HTML][HTML] Comprehensive clinical staging for resectable lung cancer: clinicopathological correlations and the role of brain MRI

J Vernon, N Andruszkiewicz, L Schneider… - Journal of Thoracic …, 2016 - Elsevier
Introduction In our model of comprehensive clinical staging (CCS) for lung cancer, patients
with a computerized tomography scan of the chest and upper abdomen not showing distant …

Diagnostic impact of integrated 18F-FDG PET/MRI in cerebral staging of patients with non-small cell lung cancer

C Deuschl, F Nensa, J Grueneisen… - Acta …, 2017 - journals.sagepub.com
Background Integrated positron emission tomography/magnetic resonance imaging
(PET/MRI) systems are increasingly being available and used for staging examinations …

[HTML][HTML] Brain Imaging in Patients with Non-Small Cell Lung Cancer—A Systematic Review

N Mayer, L Boschetti, M Scarci, U Cioffi… - Journal of Clinical …, 2025 - mdpi.com
Background: Lung cancer frequently metastasizes to the brain, liver, and adrenal glands
with a significant negative prognostic impact on overall survival and quality of life (QoL). To …