Regulatory mechanisms and promising applications of quorum sensing-inhibiting agents in control of bacterial biofilm formation

L Zhou, Y Zhang, Y Ge, X Zhu, J Pan - Frontiers in microbiology, 2020 - frontiersin.org
A biofilm is an assemblage of microbial cells attached to a surface and encapsulated in an
extracellular polymeric substance (EPS) matrix. The formation of a biofilm is one of the …

The hierarchy quorum sensing network in Pseudomonas aeruginosa

J Lee, L Zhang - Protein & cell, 2015 - academic.oup.com
Pseudomonas aeruginosa causes severe and persistent infections in immune compromised
individuals and cystic fibrosis sufferers. The infection is hard to eradicate as P. aeruginosa …

The Formation of Biofilms by Pseudomonas aeruginosa: A Review of the Natural and Synthetic Compounds Interfering with Control Mechanisms

T Rasamiravaka, Q Labtani, P Duez… - BioMed research …, 2015 - Wiley Online Library
P. aeruginosa is an opportunistic pathogenic bacterium responsible for both acute and
chronic infections. Beyond its natural resistance to many drugs, its ability to form biofilm, a …

The Pseudomonas aeruginosa lectin LecB binds to the exopolysaccharide Psl and stabilizes the biofilm matrix

D Passos da Silva, ML Matwichuk… - Nature …, 2019 - nature.com
Pseudomonas aeruginosa biofilms are composed of exopolysaccharides (EPS), exogenous
DNA, and proteins that hold these communities together. P. aeruginosa produces lectins …

Quorum sensing in bacteria

MB Miller, BL Bassler - Annual Reviews in Microbiology, 2001 - annualreviews.org
▪ Abstract Quorum sensing is the regulation of gene expression in response to fluctuations in
cell-population density. Quorum sensing bacteria produce and release chemical signal …

Antimicrobial resistance, respiratory tract infections and role of biofilms in lung infections in cystic fibrosis patients

O Ciofu, T Tolker-Nielsen, PØ Jensen, H Wang… - Advanced drug delivery …, 2015 - Elsevier
Lung infection is the main cause of morbidity and mortality in patients with cystic fibrosis and
is mainly dominated by Pseudomonas aeruginosa. The biofilm mode of growth makes …

Quinolones: from antibiotics to autoinducers

S Heeb, MP Fletcher, SR Chhabra… - FEMS microbiology …, 2011 - academic.oup.com
Since quinine was first isolated, animals, plants and microorganisms producing a wide
variety of quinolone compounds have been discovered, several of which possess …

Novel Strategies for the Treatment of Pseudomonas aeruginosa Infections

S Wagner, R Sommer, S Hinsberger, C Lu… - Journal of medicinal …, 2016 - ACS Publications
Infections with Pseudomonas aeruginosa have become a concerning threat in hospital-
acquired infections and for cystic fibrosis patients. The major problem leading to high …

From carbohydrate leads to glycomimetic drugs

B Ernst, JL Magnani - Nature reviews Drug discovery, 2009 - nature.com
Carbohydrates are the most abundant natural products. Besides their role in metabolism
and as structural building blocks, they are fundamental constituents of every cell surface …

Quorum-sensing in Gram-negative bacteria

NA Whitehead, AML Barnard, H Slater… - FEMS microbiology …, 2001 - academic.oup.com
It has become increasingly and widely recognised that bacteria do not exist as solitary cells,
but are colonial organisms that exploit elaborate systems of intercellular communication to …