A vagal–brainstem interoceptive circuit for cough-like defensive behaviors in mice
Coughing is a respiratory behavior that plays a crucial role in protecting the respiratory
system. Here we show that the nucleus of the solitary tract (NTS) in mice contains …
system. Here we show that the nucleus of the solitary tract (NTS) in mice contains …
Central mechanisms of emesis: A role for GDF15
T Borner, AM Pataro… - Neurogastroenterology & …, 2024 - Wiley Online Library
Background Nausea and emesis are ubiquitously reported medical conditions and often
present as treatment side effects along with polymorbidities contributing to detrimental life …
present as treatment side effects along with polymorbidities contributing to detrimental life …
Single nucleus transcriptomic analysis of rat nucleus accumbens reveals cell type-specific patterns of gene expression associated with volitional morphine intake
Opioid exposure is known to cause transcriptomic changes in the nucleus accumbens
(NAc). However, no studies to date have investigated cell type-specific transcriptomic …
(NAc). However, no studies to date have investigated cell type-specific transcriptomic …
[HTML][HTML] GIP receptor agonism blocks chemotherapy-induced nausea and vomiting
Objective Nausea and vomiting remain life-threatening obstacles to successful treatment of
chronic diseases, despite a cadre of available antiemetic medications. Our inability to …
chronic diseases, despite a cadre of available antiemetic medications. Our inability to …
[HTML][HTML] Body weight lowering effect of glucose-dependent insulinotropic polypeptide and glucagon-like peptide receptor agonists is more efficient in RAMP1/3 KO …
The glucose-dependent insulinotropic polypeptide (GIPR) and glucagon-like peptide (GLP-
1R) receptor agonists are insulin secretagogues that have long been shown to improve …
1R) receptor agonists are insulin secretagogues that have long been shown to improve …
Locus coeruleus vulnerability to tau hyperphosphorylation in a rat model
T Omoluabi, Z Hasan, JE Piche, ARS Flynn… - Aging …, 2024 - Wiley Online Library
Post‐mortem investigations indicate that the locus coeruleus (LC) is the initial site of
hyperphosphorylated pretangle tau, a precursor to neurofibrillary tangles (NFTs) found in …
hyperphosphorylated pretangle tau, a precursor to neurofibrillary tangles (NFTs) found in …
GPR-160 receptor signaling in the dorsal vagal complex of male rats modulates meal microstructure and CART-mediated hypophagia
The g-protein coupled receptor GPR-160, recently identified as a putative receptor for the
cocaine and amphetamine-regulated transcript (CART) peptide, shows abundant …
cocaine and amphetamine-regulated transcript (CART) peptide, shows abundant …
Molecular Ontology of the Nucleus of Solitary Tract
S Gasparini, G Almeida‐Pereira… - Journal of …, 2024 - Wiley Online Library
The nucleus of the solitary tract (NTS) receives visceral information and regulates appetitive,
digestive, and cardiorespiratory systems. Within the NTS, diverse processes operate in …
digestive, and cardiorespiratory systems. Within the NTS, diverse processes operate in …
Brain circuits for retching-like behavior
L Huo, Z Ye, M Liu, Z He, M Huang, D Li… - National Science …, 2024 - academic.oup.com
Nausea and vomiting are important defensive responses to cope with pathogens and toxins
that invade the body. The nucleus of the solitary tract (NTS) is important for initiating these …
that invade the body. The nucleus of the solitary tract (NTS) is important for initiating these …
An endogenous GLP-1 circuit engages VTA GABA neurons to regulate mesolimbic dopamine neurons and attenuate cocaine seeking
Recent studies show that systemic administration of a glucagon-like peptide-1 receptor (GLP-
1R) agonist is sufficient to attenuate the reinstatement of cocaine-seeking behavior, an …
1R) agonist is sufficient to attenuate the reinstatement of cocaine-seeking behavior, an …