Primary immunodeficiency and autoimmunity: a comprehensive review
The primary immunodeficiency diseases (PIDs) include many genetic disorders that affect
different components of the innate and adaptive responses. The number of distinct genetic …
different components of the innate and adaptive responses. The number of distinct genetic …
The ITP syndrome: pathogenic and clinical diversity
DB Cines, JB Bussel, HA Liebman… - Blood, The Journal of …, 2009 - ashpublications.org
Immune thrombocytopenia (ITP) is mediated by platelet autoantibodies that accelerate
platelet destruction and inhibit their production. Most cases are considered idiopathic …
platelet destruction and inhibit their production. Most cases are considered idiopathic …
Human T-bet governs the generation of a distinct subset of CD11chighCD21low B cells
High-level expression of the transcription factor T-bet characterizes a phenotypically distinct
murine B cell population known as “age-associated B cells”(ABCs). T-bet–deficient mice …
murine B cell population known as “age-associated B cells”(ABCs). T-bet–deficient mice …
International Consensus Document (ICON): common variable immunodeficiency disorders
FA Bonilla, I Barlan, H Chapel… - The journal of …, 2015 - pmc.ncbi.nlm.nih.gov
The International Collaboration in Asthma, Allergy and Immunology initiated an international
coalition among the American Academy of Allergy, Asthma & Immunology; the European …
coalition among the American Academy of Allergy, Asthma & Immunology; the European …
Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4
Cytotoxic T lymphocyte antigen–4 (CTLA-4) is an inhibitory receptor found on immune cells.
The consequences of mutations in CTLA4 in humans are unknown. We identified germline …
The consequences of mutations in CTLA4 in humans are unknown. We identified germline …
Morbidity and mortality in common variable immune deficiency over 4 decades
ES Resnick, EL Moshier, JH Godbold… - Blood, The Journal …, 2012 - ashpublications.org
The demographics, immunologic parameters, medical complications, and mortality statistics
from 473 subjects with common variable immune deficiency followed over 4 decades in New …
from 473 subjects with common variable immune deficiency followed over 4 decades in New …
Common variable immunodeficiency disorders: division into distinct clinical phenotypes
H Chapel, M Lucas, M Lee, J Bjorkander… - Blood, The Journal …, 2008 - ashpublications.org
Abstract The European Common Variable Immunodeficiency Disorders registry was started
in 1996 to define distinct clinical phenotypes and determine overlap within individual …
in 1996 to define distinct clinical phenotypes and determine overlap within individual …
Practice parameter for the diagnosis and management of primary immunodeficiency
FA Bonilla, DA Khan, ZK Ballas, J Chinen… - Journal of Allergy and …, 2015 - Elsevier
The American Academy of Allergy, Asthma & Immunology (AAAAI) and the American
College of Allergy, Asthma & Immunology (ACAAI) have jointly accepted responsibility for …
College of Allergy, Asthma & Immunology (ACAAI) have jointly accepted responsibility for …
The EUROclass trial: defining subgroups in common variable immunodeficiency
C Wehr, T Kivioja, C Schmitt, B Ferry… - Blood, The Journal …, 2008 - ashpublications.org
The heterogeneity of common variable immunodeficiency (CVID) calls for a classification
addressing pathogenic mechanisms as well as clinical relevance. This European …
addressing pathogenic mechanisms as well as clinical relevance. This European …
Common variable immunodeficiency: epidemiology, pathogenesis, clinical manifestations, diagnosis, classification, and management.
Common variable immunodeficiency (CVID) is a heterogeneous disorder characterized by
hypogammaglobulinemia and increased susceptibility to recurrent bacterial infections. It is …
hypogammaglobulinemia and increased susceptibility to recurrent bacterial infections. It is …