Skeletal muscles are essential for vital functions such as movement, postural support,
breathing, and thermogenesis. Muscle tissue is largely composed of long, postmitotic …

Dystrophin is a long rod-shaped protein that connects the subsarcolemmal cytoskeleton to a
complex of proteins in the surface membrane (dystrophin protein complex, DPC), with further …

Telomere shortening in somatic tissues largely reflects stem cell replication. Previous human
studies of telomere attrition were predominantly conducted on leukocytes. However, findings …

Chargé, Sophie BP, and Michael A. Rudnicki. Cellular and Molecular Regulation of Muscle
Regeneration. Physiol Rev 84: 209–238, 2004; 10.1152/physrev. 00019.2003.—Under …

Satellite cells, the quintessential skeletal muscle stem cells, reside in a specialized local
environment whose anatomy changes dynamically during tissue regeneration. The plasticity …

Adult skeletal muscle has a remarkable ability to regenerate following myotrauma. Because
adult myofibers are terminally differentiated, the regeneration of skeletal muscle is largely …

In Duchenne muscular dystrophy (DMD), dystrophin mutation leads to progressive lethal
skeletal muscle degeneration. For unknown reasons, dystrophin deficiency does not …

Skeletal muscle continuously adapts to changes in its mechanical environment through
modifications in gene expression and protein stability that affect its physiological function …

Physical activity relies on muscular force. In adult skeletal muscle, force results from the
contraction of postmitotic, multinucleated myofibres of different contractile and metabolic …

Most normal human cells undergo cellular senescence after accruing a fixed number of cell
divisions, or are challenged by a variety of potentially oncogenic stimuli, in culture and most …