Phagocytosis is a remarkably complex and versatile process: it contributes to innate
immunity through the ingestion and elimination of pathogens, while also being central to …

Malignant cancer cells utilize their intrinsic migratory ability to invade adjacent tissues and
the vasculature, and ultimately to metastasize. Cell migration is the sum of multi-step …

Animal cell shape is largely determined by the cortex, a thin actin network underlying the
plasma membrane in which myosin-driven stresses generate contractile tension. Tension …

Dendritic cells constitutively secrete a population of small (50–90 nm diameter) Ag-
presenting vesicles called exosomes. When sensitized with tumor antigenic peptides …

Brief periods of sleep loss have long-lasting consequences such as impaired memory
consolidation. Structural changes in synaptic connectivity have been proposed as a …

MicroRNAs are small, non-coding RNAs that control the translation of target messenger
RNAs, thereby regulating critical aspects of plant and animal development. In the …

Proteins of the actin depolymerizing factor (ADF)/cofilin family are ubiquitous among
eukaryotes and are essential regulators of actin dynamics and function. Mammalian neurons …

The actin depolymerizing factor (ADF)/cofilin family comprises small actin-binding proteins
with crucial roles in development, tissue homeostasis and disease. They are best known for …

The actin cytoskeleton is a complex structure that performs a wide range of cellular
functions. In 2001, significant advances were made to our understanding of the structure and …

Haploinsufficiency of the Shank3 gene, which encodes a scaffolding protein at glutamatergic
synapses, is a highly prevalent and penetrant risk factor for autism. Using combined …