The reactive oxygen species (ROS)-producing enzyme NADPH oxidase (NOX) was first
identified in the membrane of phagocytic cells. For many years, its only known role was in …

Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

Reactive oxygen species (ROS) are pervasive signaling molecules in biological systems. In
humans, a lack of ROS causes chronic and extreme bacterial infections, while uncontrolled …

Phagocyte oxidase plays an essential role in the first line of host defense against pathogens.
It oxidizes intracellular NADPH to reduce extracellular oxygen to produce superoxide anions …

Redox reactions have been established as major biological players in many cellular
signaling pathways. Here we review mechanisms of redox signaling with an emphasis on …

P22 phox is a ubiquitous protein encoded by the CYBA gene located on the long arm of
chromosome 16 at position 24, containing six exons and spanning 8.5 kb. P22 phox is a …

Phagocyte superoxide production by a multicomponent NADPH oxidase is important in host
defense against microbial invasion. However inappropriate NADPH oxidase activation …

NADPH oxidase 2 is a superoxide-generating enzymatic complex based on the catalytic
subunit gp91phox that is also known as Nox2. Initially identified in neutrophils, NADPH …

NADPH oxidases (N ox) are membrane complexes that produce O2−. Researches in
mammals, plants and fungi highlight the involvement of Nox‐generated ROS in cell …

The key purpose of phagocytosis is the destruction of pathogenic microorganisms. The
phagocytes exert a wide array of killing mechanisms that allow mastering the vast majority of …