Systems biology and synthetic biology are increasingly used to examine and modulate
complex biological systems. As such, many issues arising during scaling-up microbial …

Gradients in industrial bioreactors have attracted substantial research attention since
exposure to fluctuating environmental conditions has been shown to lead to changes in the …

Bioprocess scale-up is a critical step in process development. However, loss of production
performance upon scaling-up, including reduced titer, yield, or productivity, has often been …

Industrial biotechnological production is developing rapidly worldwide. Consequently, more
and novel bioprocesses need to perform optimally not only in small lab-but also in large …

The trajectories, referred to as lifelines, of individual microorganisms in an industrial scale
fermentor under substrate limiting conditions were studied using an Euler‐Lagrange …

We assess the effect of substrate heterogeneity on the metabolic response of P.
chrysogenum in industrial bioreactors via the coupling of a 9-pool metabolic model with …

With reaction timescales equal to or shorter than the circulation time, the ideal mixing
assumption typically does not hold for large scale bioreactors. As a consequence large …

Euler‐Lagrange CFD simulations, where the biotic phase is represented by computational
particles (parcels), provide information on environmental gradients inside bioreactors from …

This paper describes a simulation of an industrial-scale fed-batch fermentation that can be
used as a benchmark in process systems analysis and control studies. The simulation was …

Cytosolic acetyl-coenzyme A is a precursor for many biotechnologically relevant compounds
produced by Saccharomyces cerevisiae. In this yeast, cytosolic acetyl-CoA synthesis and …