Background: The range of benefits associated with regular physical activity participation is
irrefutable. Despite the well-known benefits, physical inactivity remains one of the major …

Clinicians, institutions, and policy makers use results from randomized controlled trials to
make decisions regarding therapeutic interventions for their patients and populations …

Background Studies that have evaluated the use of intravenous vitamin C in adults with
sepsis who were receiving vasopressor therapy in the intensive care unit (ICU) have shown …

Background Haloperidol is frequently used to treat delirium in patients in the intensive care
unit (ICU), but evidence of its effect is limited. Methods In this multicenter, blinded, placebo …

This chapter details version 2 of the Cochrane risk‐of‐bias tool for randomized trials (RoB
2), the recommended tool for use in Cochrane Reviews. The RoB 2 tool is structured into …

Assessment of risk of bias is regarded as an essential component of a systematic review on
the effects of an intervention. The most commonly used tool for randomised trials is the …

Vector-borne diseases (VBDs), including malaria, dengue and leishmaniasis, cause
considerable morbidity and mortality in tropical regions of the world. Vector control methods …

Background The effects of delayed cord clamping of the umbilical cord in preterm infants are
unclear. Objective We sought to compare the effects of delayed vs early cord clamping on …

Importance Previous trials have suggested that vasopressin and methylprednisolone
administered during in-hospital cardiac arrest might improve outcomes. Objective To …

Background Unconscious survivors of out-of-hospital cardiac arrest have a high risk of death
or poor neurologic function. Therapeutic hypothermia is recommended by international …