Human cytomegalovirus (HCMV) infection is associated with severe morbidity and mortality
in immunocompromised individuals, in particular transplant recipients and AIDS patients …

DNA glycosylases are enzymes that initiate the base excision repair pathway, a major
biochemical process that protects the genomes of all living organisms from intrinsically and …

Publisher Summary Uracil residues are introduced into prokaryotic and eukaryotic
deoxyribonucleic acid (DNA) as a normal physiological process during DNA synthesis, and …

Human herpesviruses are found worldwide and are among the most frequent causes of viral
infections in immunocompetent as well as in immunocompromised patients. During the past …

Mycobacterium tuberculosi s uracil-DNA glycosylase (Mt Ung), a key DNA repair enzyme,
represents an attractive target for the design of new antimycobacterial agents. However, only …

The quiet pandemic of herpes simplex virus (HSV) infections has plagued humanity since
ancient times, causing mucocutaneous infection such as herpes labialis and herpes …

Base excision repair is a major mechanism for correcting aberrant DNA bases. We are using
an in vitro base excision repair assay to fractionate and purify proteins from a human cell …

The quiet pandemic of herpes simplex virus (HSV) infection has plagued humanity since
ancient times, causing mucocutaneous infection, such as herpes labialis and herpes …

Uracil–DNA glycosylases are enzymes that excise uracil bases appearing in DNA as a
result of cytosine deamination or accidental dUMP incorporation from the dUTP pool. The …

Uracil-DNA glycosylase (UNG), a repair enzyme involved in the excision of uracil from DNA,
from mycobacteria differs from UNGs from other sources, particularly in the sequence in the …