Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications
SJ Serrano-Gomez, M Maziveyi, SK Alahari - Molecular cancer, 2016 - Springer
The epithelial to mesenchymal transition (EMT) is a biological process in which a non-motile
epithelial cell changes to a mesenchymal phenotype with invasive capacities. This …
epithelial cell changes to a mesenchymal phenotype with invasive capacities. This …
TGF-β signaling and epithelial–mesenchymal transition in cancer progression
Y Katsuno, S Lamouille, R Derynck - Current opinion in oncology, 2013 - journals.lww.com
The differentiation plasticity of epithelial cells that mediates TGF-β-induced EMT and
reversion from mesenchymal to epithelial phenotype are increasingly seen as integral …
reversion from mesenchymal to epithelial phenotype are increasingly seen as integral …
Understanding the language of Lys36 methylation at histone H3
EJ Wagner, PB Carpenter - Nature reviews Molecular cell biology, 2012 - nature.com
Histone side chains are post-translationally modified at multiple sites, including at Lys36 on
histone H3 (H3K36). Several enzymes from yeast and humans, including the …
histone H3 (H3K36). Several enzymes from yeast and humans, including the …
Inhibitors of protein methyltransferases and demethylases
Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …
histone demethylases (KDMs) play an important role in the regulation of gene expression …
NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis
The etiological role of NSD2 enzymatic activity in solid tumors is unclear. Here we show that
NSD2, via H3K36me2 catalysis, cooperates with oncogenic KRAS signaling to drive lung …
NSD2, via H3K36me2 catalysis, cooperates with oncogenic KRAS signaling to drive lung …
Greater than the sum of parts: complexity of the dynamic epigenome
AA Soshnev, SZ Josefowicz, CD Allis - Molecular cell, 2016 - cell.com
Information encoded in DNA is interpreted, modified, and propagated as chromatin. The
diversity of inputs encountered by eukaryotic genomes demands a matching capacity for …
diversity of inputs encountered by eukaryotic genomes demands a matching capacity for …
Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 …
R Popovic, E Martinez-Garcia, EG Giannopoulou… - PLoS …, 2014 - journals.plos.org
Overexpression of the histone methyltransferase MMSET in t (4; 14)+ multiple myeloma
patients is believed to be the driving factor in the pathogenesis of this subtype of myeloma …
patients is believed to be the driving factor in the pathogenesis of this subtype of myeloma …
The role of nuclear receptor–binding SET domain family histone lysine methyltransferases in cancer
RL Bennett, A Swaroop… - Cold Spring …, 2017 - perspectivesinmedicine.cshlp.org
The nuclear receptor–binding SET Domain (NSD) family of histone H3 lysine 36
methyltransferases is comprised of NSD1, NSD2 (MMSET/WHSC1), and NSD3 (WHSC1L1) …
methyltransferases is comprised of NSD1, NSD2 (MMSET/WHSC1), and NSD3 (WHSC1L1) …
An epigenomic approach to therapy for tamoxifen-resistant breast cancer
Tamoxifen has been a frontline treatment for estrogen receptor alpha (ERα)-positive breast
tumors in premenopausal women. However, resistance to tamoxifen occurs in many …
tumors in premenopausal women. However, resistance to tamoxifen occurs in many …
Reversible LSD1 inhibition interferes with global EWS/ETS transcriptional activity and impedes Ewing sarcoma tumor growth
S Sankar, ER Theisen, J Bearss, T Mulvihill… - Clinical cancer …, 2014 - AACR
Purpose: Ewing sarcoma is a pediatric bone tumor that absolutely relies on the
transcriptional activity of the EWS/ETS family of fusion oncoproteins. While the most common …
transcriptional activity of the EWS/ETS family of fusion oncoproteins. While the most common …