Since its discovery, the STAT3 transcription factor has been extensively studied for its
function as a transcriptional regulator and its role as a mediator of development, normal …

AMP-activated protein kinase (AMPK) is an important mediator in maintaining cellular
energy homeostasis. AMPK is activated in response to a shortage of energy. Once activated …

Plasticity in energy metabolism allows stem cells to match the divergent demands of self-
renewal and lineage specification. Beyond a role in energetic support, new evidence …

Summary c-Myc (Myc) is an important transcriptional regulator in embryonic stem (ES) cells,
somatic cell reprogramming, and cancer. Here, we identify a Myc-centered regulatory …

As is the case for embryo-derived stem cells, application of reprogrammed human induced
pluripotent stem cells is limited by our understanding of lineage specification. Here we …

The Wnt1 protein, a secreted ligand that activates Wnt signaling pathways, contributes to the
self-renewal of cancer stem cells (CSCs) and thus may be a major determinant of tumor …

Metabolism is influenced by age, food intake, and conditions such as diabetes and obesity.
How do physiological or pathological metabolic changes influence stem cells, which are …

Signaling via the Akt serine/threonine protein kinase plays critical roles in the self-renewal of
embryonic stem cells and their malignant counterpart, embryonal carcinoma cells (ECCs) …

Significance: Stem cell activation and differentiation occur along changes in cellular
metabolism. Metabolic transitions translate into changes in redox balance, cell signaling …

Despite advances in cancer therapeutics and the integration of personalized medicine, the
development of chemoresistance in many patients remains a significant contributing factor to …