The significant other: splicing by the minor spliceosome
The removal of non‐coding sequences, introns, from the mRNA precursors is an essential
step in eukaryotic gene expression. U12‐type introns are a minor subgroup of introns …
step in eukaryotic gene expression. U12‐type introns are a minor subgroup of introns …
Splicing of a rare class of introns by the U12-dependent spliceosome
CL Will, R Lührmann - 2005 - degruyter.com
Pre-mRNA splicing is catalyzed by two unique spliceosomes, designated U2-or U12-
dependent. In contrast to the well-characterized U2-dependent spliceosome, much remains …
dependent. In contrast to the well-characterized U2-dependent spliceosome, much remains …
[HTML][HTML] Evolution of genes and genomes on the Drosophila phylogeny
Comparative analysis of multiple genomes in a phylogenetic framework dramatically
improves the precision and sensitivity of evolutionary inference, producing more robust …
improves the precision and sensitivity of evolutionary inference, producing more robust …
Comprehensive splice-site analysis using comparative genomics
We have collected over half a million splice sites from five species—Homo sapiens, Mus
musculus, Drosophila melanogaster, Caenorhabditis elegans and Arabidopsis thaliana …
musculus, Drosophila melanogaster, Caenorhabditis elegans and Arabidopsis thaliana …
Complex spliceosomal organization ancestral to extant eukaryotes
L Collins, D Penny - Molecular biology and evolution, 2005 - academic.oup.com
In higher eukaryotes, introns are spliced out of protein-coding mRNAs by the spliceosome, a
massive complex comprising five non-coding RNAs (ncRNAs) and about 200 proteins. By …
massive complex comprising five non-coding RNAs (ncRNAs) and about 200 proteins. By …
U12DB: a database of orthologous U12-type spliceosomal introns
TS Alioto - Nucleic acids research, 2007 - academic.oup.com
U12-type introns are spliced by the U12-dependent spliceosome and are present in the
genomes of many higher eukaryotic lineages including plants, chordates and some …
genomes of many higher eukaryotic lineages including plants, chordates and some …
An early evolutionary origin for the minor spliceosome
AG Russell, JM Charette, DF Spencer, MW Gray - Nature, 2006 - nature.com
The minor spliceosome is a ribonucleoprotein complex that catalyses the removal of an
atypical class of spliceosomal introns (U12-type) from eukaryotic messenger RNAs,. It was …
atypical class of spliceosomal introns (U12-type) from eukaryotic messenger RNAs,. It was …
Evolution of spliceosomal snRNA genes in metazoan animals
While studies of the evolutionary histories of protein families are commonplace, little is
known on noncoding RNAs beyond microRNAs and some snoRNAs. Here we investigate in …
known on noncoding RNAs beyond microRNAs and some snoRNAs. Here we investigate in …
A Drosophila model of spinal muscular atrophy uncouples snRNP biogenesis functions of survival motor neuron from locomotion and viability defects
K Praveen, Y Wen, AG Matera - Cell reports, 2012 - cell.com
The spinal muscular atrophy (SMA) protein, survival motor neuron (SMN), functions in the
biogenesis of small nuclear ribonucleoproteins (snRNPs). SMN has also been implicated in …
biogenesis of small nuclear ribonucleoproteins (snRNPs). SMN has also been implicated in …
Evolutionary conservation of minor U12-type spliceosome between plants and humans
ZJ Lorković, R Lehner, C Forstner, A Barta - Rna, 2005 - rnajournal.cshlp.org
Splicing of rare, U12-type or AT-AC introns is mediated by a distinct spliceosome that
assembles from U11, U12, U4atac, U6atac, and U5 snRNPs. Although in human cells the …
assembles from U11, U12, U4atac, U6atac, and U5 snRNPs. Although in human cells the …