Diversity and inter-connections in the CXCR4 chemokine receptor/ligand family: molecular perspectives
L Pawig, C Klasen, C Weber, J Bernhagen… - Frontiers in …, 2015 - frontiersin.org
CXCR4 and its ligand CXCL12 mediate the homing of progenitor cells in the bone marrow
and their recruitment to sites of injury, as well as affect processes such as cell arrest …
and their recruitment to sites of injury, as well as affect processes such as cell arrest …
The angiotensin receptor blocker losartan suppresses growth of pulmonary metastases via AT1R-independent inhibition of CCR2 signaling and monocyte recruitment
Inflammatory monocytes have been shown to play key roles in cancer metastasis through
promotion of tumor cell extravasation, growth, and angiogenesis. Monocyte recruitment to …
promotion of tumor cell extravasation, growth, and angiogenesis. Monocyte recruitment to …
Heteromerization of chemokine (CXC motif) receptor 4 with α1A/B-adrenergic receptors controls α1-adrenergic receptor function
A Tripathi, PG Vana, TS Chavan… - Proceedings of the …, 2015 - National Acad Sciences
Recent evidence suggests that chemokine (CXC motif) receptor 4 (CXCR4) contributes to
the regulation of blood pressure through interactions with α1-adrenergic receptors (ARs) in …
the regulation of blood pressure through interactions with α1-adrenergic receptors (ARs) in …
RNA-seq analysis reveals CCR5 as a key target for CRISPR gene editing to regulate in vivo NK cell trafficking
ER Levy, JA Clara, RN Reger, DSJ Allan, RW Childs - Cancers, 2021 - mdpi.com
Simple Summary Adoptive immunotherapy utilizing ex vivo expanded natural killer (NK)
cells is being explored in the clinical and preclinical settings to treat hematological tumors …
cells is being explored in the clinical and preclinical settings to treat hematological tumors …
α1B/D-adrenoceptors regulate chemokine receptor–mediated leukocyte migration via formation of heteromeric receptor complexes
GA Enten, X Gao, HR Strzelinski… - Proceedings of the …, 2022 - National Acad Sciences
It is known that catecholamines regulate innate immune functions. The underlying
mechanisms, however, are not well understood. Here we show that at least 20 members of …
mechanisms, however, are not well understood. Here we show that at least 20 members of …
Use of extracellular monomeric ubiquitin as a therapeutic option for major depressive disorder
JL Maldonado-García, LH García-Mena… - Pharmaceuticals, 2024 - mdpi.com
Major depressive disorder (MDD) is a mood disorder that has become a global health
emergency according to the World Health Organization (WHO). It affects 280 million people …
emergency according to the World Health Organization (WHO). It affects 280 million people …
New insights into mechanisms and functions of chemokine (CXC motif) receptor 4 heteromerization in vascular smooth muscle
AE Evans, A Tripathi, HM LaPorte… - International journal of …, 2016 - mdpi.com
Recent evidence suggests that CXC chemokine receptor type 4 (CXCR4) heteromerizes
with α1A/B-adrenoceptors (AR) and atypical chemokine receptor 3 (ACKR3) and that …
with α1A/B-adrenoceptors (AR) and atypical chemokine receptor 3 (ACKR3) and that …
α1‐Adrenergic Receptors Function Within Hetero‐Oligomeric Complexes With Atypical Chemokine Receptor 3 and Chemokine (C‐X‐C motif) Receptor 4 in Vascular …
LJ Albee, JM Eby, A Tripathi, HM LaPorte… - Journal of the …, 2017 - Am Heart Assoc
Background Recently, we provided evidence that α1‐adrenergic receptors (ARs) in vascular
smooth muscle are regulated by chemokine (C‐X‐C motif) receptor (CXCR) 4 and atypical …
smooth muscle are regulated by chemokine (C‐X‐C motif) receptor (CXCR) 4 and atypical …
Exogenous ubiquitin reduces inflammatory response and preserves myocardial function 3 days post-ischemia-reperfusion injury
SLC Scofield, S Dalal, KA Lim… - American Journal …, 2019 - journals.physiology.org
β-Adrenergic receptor (β-AR) stimulation increases extracellular levels of ubiquitin (UB) in
myocytes, and exogenous UB decreases β-AR-stimulated myocyte apoptosis and …
myocytes, and exogenous UB decreases β-AR-stimulated myocyte apoptosis and …
NMMHC-IIA-dependent nuclear location of CXCR4 promotes migration and invasion in renal cell carcinoma
Z Xu, P Li, D Wei, Z Wang, Y Bao, J Sun… - Oncology …, 2016 - spandidos-publications.com
The chemokine receptor cysteine (C)-XC receptor (CXCR4) is a G-protein-coupled receptor
that exerts a vital role in distant metastasis of renal cell carcinoma (RCC). Emerging …
that exerts a vital role in distant metastasis of renal cell carcinoma (RCC). Emerging …