Peptidoglycan NlpC/P60 peptidases in bacterial physiology and host interactions

ME Griffin, S Klupt, J Espinosa, HC Hang - Cell chemical biology, 2023 - cell.com
The bacterial cell wall is composed of a highly crosslinked matrix of glycopeptide polymers
known as peptidoglycan that dictates bacterial cell morphology and protects against …

Homeostatic control of cell wall hydrolysis by the WalRK two-component signaling pathway in Bacillus subtilis

GS Dobihal, YR Brunet, J Flores-Kim, DZ Rudner - elife, 2019 - elifesciences.org
Bacterial cells are encased in a peptidoglycan (PG) exoskeleton that protects them from
osmotic lysis and specifies their distinct shapes. Cell wall hydrolases are required to enlarge …

Structural basis of peptidoglycan endopeptidase regulation

JH Shin, AG Sulpizio, A Kelley… - Proceedings of the …, 2020 - National Acad Sciences
Most bacteria surround themselves with a cell wall, a strong meshwork consisting primarily
of the polymerized aminosugar peptidoglycan (PG). PG is essential for structural …

Peptidoglycan structure, biosynthesis, and dynamics during bacterial growth

A Walter, C Mayer - Extracellular sugar-based biopolymers matrices, 2019 - Springer
The peptidoglycan is the key structural component of the bacterial cell wall that rests outside
the cytoplasmic membrane and provides bacterial cells with physical strength and shape. It …

Comparative Analysis of Structural Variations Due to Genome Shuffling of Bacillus Subtilis VS15 for Improved Cellulase Production

SL Ega, G Drendel, S Petrovski, E Egidi… - International journal of …, 2020 - mdpi.com
Cellulose is one of the most abundant and renewable biomass products used for the
production of bioethanol. Cellulose can be efficiently hydrolyzed by Bacillus subtilis VS15, a …

Transcriptome analysis and prediction of the metabolic state of stress-induced viable but non-culturable Bacillus subtilis cells

LP Morawska, OP Kuipers - Scientific Reports, 2022 - nature.com
Many bacteria adapt their physiology and enter the viable but non-culturable state to survive
prolonged exposure to adverse environmental conditions. The VBNC cells maintain active …

The characteristics of autolysins associated with cell separation in Bacillus subtilis

R Li, R Chu, R Ban - Journal of Bacteriology, 2024 - journals.asm.org
The peptidoglycan hydrolases responsible for the cell separation of Bacillus subtilis cells are
collectively referred to as autolysins. However, the role of each autolysin in the cell …

WhyD tailors surface polymers to prevent premature bacteriolysis and direct cell elongation in Streptococcus pneumoniae

J Flores-Kim, GS Dobihal, TG Bernhardt, DZ Rudner - Elife, 2022 - elifesciences.org
Penicillin and related antibiotics disrupt cell wall synthesis in bacteria causing the
downstream misactivation of cell wall hydrolases called autolysins to induce cell lysis …

CwlQ is required for swarming motility but not flagellar assembly in Bacillus subtilis

S Sanchez, CM Dunn, DB Kearns - Journal of Bacteriology, 2021 - Am Soc Microbiol
Lytic enzymes play an essential role in the remodeling of bacterial peptidoglycan (PG), an
extracellular mesh-like structure that retains the membrane in the context of high internal …

Peptidoglycan remodeling in response to cell wall acting antibiotics in Bacillus subtilis

C Cornilleau, L Alvarez, C Wegler, C Billaudeau… - bioRxiv, 2023 - biorxiv.org
Most bacteria are encased into a load-bearing rigid framework, the cell wall (CW). The
peptidoglycan (PG) layer, a network composed of glycan strands cross-linked by stem …