Dopamine signaling enriched striatal gene set predicts striatal dopamine synthesis and physiological activity in vivo

L Sportelli, DP Eisenberg, R Passiatore… - Nature …, 2024 - nature.com
The polygenic architecture of schizophrenia implicates several molecular pathways involved
in synaptic function. However, it is unclear how polygenic risk funnels through these …

Dopamine and schizophrenia from bench to bedside: Discovery of a striatal co-expression risk gene set that predicts in vivo measures of striatal function

L Sportelli, DP Eisenberg, R Passiatore, E D'Ambrosio… - bioRxiv, 2023 - biorxiv.org
Schizophrenia (SCZ) is characterized by a polygenic risk architecture implicating diverse
molecular pathways important for synaptic function. However, how polygenic risk funnels …