The evolutionary and functional significance of germline immunoglobulin gene variation
The recombination between immunoglobulin (IG) gene segments determines an individual's
naïve antibody repertoire and, consequently,(auto) antigen recognition. Emerging evidence …
naïve antibody repertoire and, consequently,(auto) antigen recognition. Emerging evidence …
The shaping of a B cell pool maximally responsive to infections
N Baumgarth - Annual review of immunology, 2021 - annualreviews.org
B cell subsets differ in development, tissue distribution, and mechanisms of activation. In
response to infections, however, all can differentiate into extrafollicular plasmablasts that …
response to infections, however, all can differentiate into extrafollicular plasmablasts that …
A TLR7-nanoparticle adjuvant promotes a broad immune response against heterologous strains of influenza and SARS-CoV-2
The ideal vaccine against viruses such as influenza and SARS-CoV-2 must provide a
robust, durable and broad immune protection against multiple viral variants. However …
robust, durable and broad immune protection against multiple viral variants. However …
Structural basis of a shared antibody response to SARS-CoV-2
Molecular understanding of neutralizing antibody responses to severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) could accelerate vaccine design and drug …
syndrome coronavirus 2 (SARS-CoV-2) could accelerate vaccine design and drug …
Linear epitope landscape of the SARS-CoV-2 Spike protein constructed from 1,051 COVID-19 patients
Y Li, M Ma, Q Lei, F Wang, W Hong, D Lai, H Hou, Z Xu… - Cell reports, 2021 - cell.com
To fully decipher the immunogenicity of the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) Spike protein, it is essential to assess which part is highly immunogenic in a …
(SARS-CoV-2) Spike protein, it is essential to assess which part is highly immunogenic in a …
B cell subsets as severity-associated signatures in COVID-19 patients
VA Sosa-Hernandez, J Torres-Ruiz… - Frontiers in …, 2020 - frontiersin.org
Background SARS-CoV-2 infection represents a global health problem that has affected
millions of people. The fine host immune response and its association with the disease …
millions of people. The fine host immune response and its association with the disease …
Immune recall improves antibody durability and breadth to SARS-CoV-2 variants
Key features of immune memory are greater and faster antigen-specific antibody responses
to repeat infection. In the setting of immune-evading viral evolution, it is important to …
to repeat infection. In the setting of immune-evading viral evolution, it is important to …
Clonal replacement sustains long-lived germinal centers primed by respiratory viruses
RVH de Carvalho, J Ersching, A Barbulescu, A Hobbs… - Cell, 2023 - cell.com
Germinal centers (GCs) form in secondary lymphoid organs in response to infection and
immunization and are the source of affinity-matured B cells. The duration of GC reactions …
immunization and are the source of affinity-matured B cells. The duration of GC reactions …
Allelic polymorphism controls autoreactivity and vaccine elicitation of human broadly neutralizing antibodies against influenza virus
M Sangesland, AT de la Peña, S Boyoglu-Barnum… - Immunity, 2022 - cell.com
Human broadly neutralizing antibodies (bnAbs) targeting the hemagglutinin stalk of group 1
influenza A viruses (IAVs) are biased for IGHV1-69 alleles that use phenylalanine (F54) but …
influenza A viruses (IAVs) are biased for IGHV1-69 alleles that use phenylalanine (F54) but …
Antigen-and scaffold-specific antibody responses to protein nanoparticle immunogens
Protein nanoparticle scaffolds are increasingly used in next-generation vaccine designs,
and several have established records of clinical safety and efficacy. Yet the rules for how …
and several have established records of clinical safety and efficacy. Yet the rules for how …