Cellular and molecular mechanisms of perineural invasion of pancreatic ductal adenocarcinoma

J Li, R Kang, D Tang - Cancer Communications, 2021 - Wiley Online Library
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignant disease with a
unique tumor microenvironment surrounded by an interlaced network of cancer and …

Hallmarks of RET and Co-occuring Genomic Alterations in RET-aberrant Cancers

JJ Adashek, AP Desai, AY Andreev-Drakhlin… - Molecular cancer …, 2021 - AACR
Activating receptor-tyrosine kinase rearranged during transfection (RET) mutations and
fusions are potent drivers of oncogenesis. The recent FDA approvals of highly potent and …

RET rearrangements in non-small cell lung cancer: Evolving treatment landscape and future challenges

A Servetto, D Esposito, R Ferrara, D Signorelli… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Abstract The Rearranged during Transfection (RET) oncogene has been extensively
investigated in solid malignancies, particularly thyroid cancer and non-small cell lung cancer …

Advances in understanding TKS4 and TKS5: Molecular scaffolds regulating cellular processes from podosome and invadopodium formation to differentiation and …

G Kudlik, T Takács, L Radnai, A Kurilla… - International Journal of …, 2020 - mdpi.com
Scaffold proteins are typically thought of as multi-domain “bridging molecules.” They serve
as crucial regulators of key signaling events by simultaneously binding multiple participants …

The cell biology of metastatic invasion in pancreatic cancer: Updates and Mechanistic Insights

VB Joshi, OL Gutierrez Ruiz, GL Razidlo - Cancers, 2023 - mdpi.com
Simple Summary Pancreatic cancer remains one of the most lethal forms of cancer, with
high rates of metastasis. Metastasis is a complex, multi-step process involving many …

Neuroscience in peripheral cancers: tumors hijacking nerves and neuroimmune crosstalk

HY Fan, XH Liang, YL Tang - MedComm, 2024 - Wiley Online Library
Cancer neuroscience is an emerging field that investigates the intricate relationship
between the nervous system and cancer, gaining increasing recognition for its importance …

Perineural invasion and associated pain transmission in pancreatic cancer

J Wang, Y Chen, X Li, X Zou - Cancers, 2021 - mdpi.com
Simple Summary Perineural invasion is a complicated process involving a series of cells
and extracellular matrix components in the tumor microenvironment, particularly the …

The role of ECM remodeling, EMT, and adhesion molecules in cancerous neural invasion: changing perspectives

A Mukherjee, P Ha, KC Wai, S Naara - Advanced Biology, 2022 - Wiley Online Library
Perineural invasion (PNI) refers to the cancerous invasion of nerves. It provides an
alternative route for metastatic invasion and can exist independently in the absence of …

A comprehensive overview of the relationship between RET gene and tumor occurrence

L Zhao, N Wang, D Zhang, Y Jia, F Kong - Frontiers in oncology, 2023 - frontiersin.org
RET gene plays significant roles in the nervous system and many other tissues. Rearranged
during transfection (RET) mutation is related to cell proliferation, invasion, and migration …

NGF-mediated crosstalk: unraveling the influence of metabolic deregulation on the interplay between neural and pancreatic cancer cells and its impact on patient …

F Trentini, V Agnetti, M Manini, E Giovannetti… - Frontiers in …, 2024 - frontiersin.org
Neural invasion is one of the most common routes of invasion in pancreatic cancer and it is
responsible for the high rate of tumor recurrence after surgery and the pain generation …