Therapeutic potential of neurotrophins for repair after brain injury: a helping hand from biomaterials

J Houlton, N Abumaria, SFR Hinkley… - Frontiers in …, 2019 - frontiersin.org
Stroke remains the leading cause of long-term disability with limited options available to aid
in recovery. Significant effort has been made to try and minimize neuronal damage following …

Circulating brain-derived neurotrophic factor as a potential biomarker in stroke: a systematic review and meta-analysis

H Mojtabavi, Z Shaka, S Momtazmanesh… - Journal of Translational …, 2022 - Springer
Background Stroke, an acute cerebrovascular event, is a leading cause of disability, placing
a significant psycho-socioeconomic burden worldwide. The adaptation and reorganization …

[HTML][HTML] Enhancing endogenous capacity to repair a stroke-damaged brain: An evolving field for stroke research

LR Zhao, A Willing - Progress in neurobiology, 2018 - Elsevier
Stroke represents a severe medical condition that causes stroke survivors to suffer from long-
term and even lifelong disability. Over the past several decades, a vast majority of stroke …

Endogenous neural stem cell responses to stroke and spinal cord injury

CA Grégoire, BL Goldenstein, EM Floriddia… - Glia, 2015 - Wiley Online Library
Stroke and spinal cord injury (SCI) are among the most frequent causes of central nervous
system (CNS) dysfunction, affecting millions of people worldwide each year. The personal …

Neuronal replacement therapy: previous achievements and challenges ahead

S Grade, M Götz - NPJ Regenerative medicine, 2017 - nature.com
Lifelong neurogenesis and incorporation of newborn neurons into mature neuronal circuits
operates in specialized niches of the mammalian brain and serves as role model for …

Exploring the therapeutic effect of neurotrophins and neuropeptides in neurodegenerative diseases: at a glance

MM Rahman, MR Islam, FA Supti, PS Dhar… - Molecular …, 2023 - Springer
Neurotrophins and neuropeptides are the essential regulators of peripheral nociceptive
nerves that help to induce, sensitize, and maintain pain. Neuropeptide has a neuroprotective …

Mesenchymal stem cells expressing brain‐derived neurotrophic factor enhance endogenous neurogenesis in an ischemic stroke model

CH Jeong, SM Kim, JY Lim, CH Ryu… - BioMed research …, 2014 - Wiley Online Library
Numerous studies have reported that mesenchymal stem cells (MSCs) can ameliorate
neurological deficits in ischemic stroke models. Among the various hypotheses that have …

Brain‐derived neurotrophic factor stimulates proliferation and differentiation of neural stem cells, possibly by triggering the Wnt/β‐catenin signaling pathway

BY Chen, X Wang, ZY Wang, YZ Wang… - Journal of …, 2013 - Wiley Online Library
Brain‐derived neurotrophic factor (BDNF) has critical functions in promoting survival,
expansion, and differentiation of neural stem cells (NSCs), but its downstream regulation …

Moderate low temperature preserves the stemness of neural stem cells and suppresses apoptosis of the cells via activation of the cold-inducible RNA binding protein

K Saito, N Fukuda, T Matsumoto, Y Iribe, A Tsunemi… - Brain research, 2010 - Elsevier
We hypothesized that one of the mechanisms underlying the protection of brain injury by
therapeutic hypothermia is associated with preservation of neural stem cells. We …

Potential therapeutic effects of neurotrophins for acute and chronic neurological diseases

J Cai, F Hua, L Yuan, W Tang, J Lu, S Yu… - BioMed research …, 2014 - Wiley Online Library
The neurotrophins (NTs) nerve growth factor (NGF), brain‐derived neurotrophic factor
(BDNF), NT‐3, and NT‐4/5 are proteins that regulate cell proliferation, differentiation, and …