Pathogenicity and virulence of Mycobacterium tuberculosis

KC Rahlwes, BRS Dias, PC Campos… - Virulence, 2023 - Taylor & Francis
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, an infectious
disease with one of the highest morbidity and mortality rates worldwide. Leveraging its …

[HTML][HTML] Consequences of genomic diversity in Mycobacterium tuberculosis

M Coscolla, S Gagneux - Seminars in immunology, 2014 - Elsevier
The causative agent of human tuberculosis, Mycobacterium tuberculosis complex (MTBC),
comprises seven phylogenetically distinct lineages associated with different geographical …

Genomic characterization of nontuberculous mycobacteria

T Fedrizzi, CJ Meehan, A Grottola, E Giacobazzi… - Scientific reports, 2017 - nature.com
Mycobacterium tuberculosis and Mycobacterium leprae have remained, for many years, the
primary species of the genus Mycobacterium of clinical and microbiological interest. The …

The complete genome sequence of Mycobacterium bovis

T Garnier, K Eiglmeier, JC Camus… - Proceedings of the …, 2003 - National Acad Sciences
Mycobacterium bovis is the causative agent of tuberculosis in a range of animal species and
man, with worldwide annual losses to agriculture of $3 billion. The human burden of …

The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system

SM Batt, DE Minnikin, GS Besra - Biochemical Journal, 2020 - portlandpress.com
Tuberculosis, caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb), is the
leading cause of death from an infectious disease, with a mortality rate of over a million …

Global phylogeography of Mycobacterium tuberculosis and implications for tuberculosis product development

S Gagneux, PM Small - The Lancet infectious diseases, 2007 - thelancet.com
New tools for controlling tuberculosis are urgently needed. Despite our emerging
understanding of the biogeography of Mycobacterium tuberculosis, the implications for …

The mycobacterial cell envelope—lipids

M Jackson - Cold Spring Harbor perspectives in …, 2014 - perspectivesinmedicine.cshlp.org
Mycobacterium tuberculosis (Mtb) lipids are indelibly imprinted in just about every key
aspect of tuberculosis (TB) basic and translational research. Although the interest in these …

A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response

MB Reed, P Domenech, C Manca, H Su, AK Barczak… - Nature, 2004 - nature.com
Fifty million new infections with Mycobacterium tuberculosis occur annually, claiming 2–3
million lives from tuberculosis worldwide. Despite the apparent lack of significant genetic …

Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis

TP Stinear, T Seemann, PF Harrison… - Genome …, 2008 - genome.cshlp.org
Mycobacterium marinum, a ubiquitous pathogen of fish and amphibia, is a near relative of
Mycobacterium tuberculosis, the etiologic agent of tuberculosis in humans. The genome of …

The Influence of Host and Bacterial Genotype on the Development of Disseminated Disease with Mycobacterium tuberculosis

M Caws, G Thwaites, S Dunstan, TR Hawn… - PLoS …, 2008 - journals.plos.org
The factors that govern the development of tuberculosis disease are incompletely
understood. We hypothesized that some strains of Mycobacterium tuberculosis (M …