Quantitative and targeted proteomics-based identification and validation of drug efficacy biomarkers

T Masuda, A Mori, S Ito, S Ohtsuki - Drug Metabolism and …, 2021 - Elsevier
Proteomics refers to the large-scale study of proteins, providing comprehensive and
quantitative information on proteins in tissue, blood, and cell samples. In many studies …

Quantification of proteins involved in drug metabolism and disposition in the human liver using label-free global proteomics

N Couto, ZM Al-Majdoub, B Achour… - Molecular …, 2019 - ACS Publications
There is an urgent need (recognized in FDA guidance, 2018) to optimize the dose of
medicines given to patients for maximal drug efficacy and limited toxicity (precision dosing) …

DCAF13 promotes breast cancer cell proliferation by ubiquitin inhibiting PERP expression

BQ Shan, XM Wang, L Zheng, Y Han, J Gao… - Cancer …, 2022 - Wiley Online Library
Evolutionarily conserved DDB1‐and CUL4‐associated factor 13 (DCAF13) is a recently
discovered substrate receptor for the cullin RING‐finger ubiquitin ligase 4 (CRL4) E3 …

Mitochondrial DNA targeting and impairment by a dinuclear Ir–Pt complex that overcomes cisplatin resistance

C Zhang, R Guan, X Liao, C Ouyang, J Liu… - Inorganic Chemistry …, 2020 - pubs.rsc.org
Mounting evidence suggests that impairment of mitochondrial DNA (mtDNA), an important
element in the response of mitochondrial biological function but more susceptible to damage …

The effect of genetic variants of SLC22A18 on proliferation, migration, and invasion of colon cancer cells

HS Song, SY Ha, JY Kim, M Kim, JH Choi - Scientific Reports, 2024 - nature.com
Solute carrier family (SLC) transporters are expressed in the digestive system and play
important roles in maintaining physiological functions in the body. In addition, SLC …

Identification of cell-surface proteins endocytosed by human brain microvascular endothelial cells in vitro

S Ito, M Oishi, S Ogata, T Uemura, PO Couraud… - Pharmaceutics, 2020 - mdpi.com
Cell-surface proteins that can endocytose into brain microvascular endothelial cells serve as
promising candidates for receptor-mediated transcytosis across the blood–brain barrier …

The Roles of Imprinted SLC22A18 and SLC22A18AS Gene Overexpression Caused by Promoter CpG Island Hypomethylation as Diagnostic and Prognostic …

JF Noguera-Uclés, L Boyero, A Salinas… - Cancers, 2020 - mdpi.com
Genomic imprinting is a process that involves one gene copy turned-off in a parent-of-origin-
dependent manner. The regulation of imprinted genes is broadly dependent on promoter …

pH-responsive composite nanomaterial engineered from silica nanoparticles and luminescent mitochondrion-targeted Pt (II) complex as anticancer agent

BA Faizullin, AR Khazieva, KV Kholin… - Journal of Molecular …, 2024 - Elsevier
The present work introduces a pH-dependent adsorption of water-soluble Pt (II) complex
with diimine and alkynylphosphonium ligands ([Pt] 2+) onto a surface of silica nanoparticles …

SLC12A8 mediates TKI resistance in EGFR-mutant lung cancer via PDK1/AKT axis

F Huang, J Cui, J Wan, X Yuan, Y Zhu, X Wu… - Journal of Cancer …, 2023 - Springer
Purpose Epidermal growth factor receptor (EGFR) mutation is a prominent driver of lung
cancer. Tyrosine kinase inhibitors (TKIs) have shown efficacy in treating EGFR-mutant lung …

[引用][C] Emerging roles of the human solute carrier 22 family

SW Yee, KM Giacomini - Drug Metabolism and Disposition, 2022 - ASPET