Celiac disease: an immunological jigsaw

B Meresse, G Malamut, N Cerf-Bensussan - Immunity, 2012 - cell.com
Celiac disease (CD) is a chronic enteropathy induced by dietary gluten in genetically
predisposed people. The keystone of CD pathogenesis is an adaptive immune response …

Genetics and pathogenesis of coeliac disease

GA Heap, DA van Heel - Seminars in immunology, 2009 - Elsevier
Coeliac disease is a common complex disease caused by a dietary intolerance to wheat
gluten. Susceptibility is determined by both environmental and genetic factors. Coeliac …

T-cell receptor recognition of HLA-DQ2–gliadin complexes associated with celiac disease

J Petersen, V Montserrat, JR Mujico, KL Loh… - Nature structural & …, 2014 - nature.com
Celiac disease is a T cell–mediated disease induced by dietary gluten, a component of
which is gliadin. 95% of individuals with celiac disease carry the HLA (human leukocyte …

Characterizations of a neutralizing antibody broadly reactive to multiple gluten peptide: HLA-DQ2. 5 complexes in the context of celiac disease

Y Okura, Y Ikawa-Teranishi, A Mizoroki… - Nature …, 2023 - nature.com
In human celiac disease (CeD) HLA-DQ2. 5 presents gluten peptides to antigen-specific
CD4+ T cells, thereby instigating immune activation and enteropathy. Targeting HLA-DQ2. 5 …

Biased T cell receptor usage directed against human leukocyte antigen DQ8-restricted gliadin peptides is associated with celiac disease

SE Broughton, J Petersen, A Theodossis, SW Scally… - Immunity, 2012 - cell.com
Celiac disease is a human leukocyte antigen (HLA)-DQ2-and/or DQ8-associated T cell-
mediated disorder that is induced by dietary gluten. Although it is established how gluten …

Posttranslational modification of gluten shapes TCR usage in celiac disease

SW Qiao, M Ráki, KS Gunnarsen, GÅ Løset… - The Journal of …, 2011 - journals.aai.org
Posttranslational modification of Ag is implicated in several autoimmune diseases. In celiac
disease, a cereal gluten-induced enteropathy with several autoimmune features, T cell …

Managing the coagulopathy of postpartum hemorrhage: an evolving role for viscoelastic hemostatic assays

SF Bell, L de Lloyd, N Preston, PW Collins - Journal of Thrombosis and …, 2023 - Elsevier
Postpartum hemorrhage (PPH) is usually caused by obstetrical complications but may be
exacerbated by hemostatic impairment. Standard laboratory tests of coagulation often take …

Diverse T cell receptor gene usage in HLA-DQ8-associated celiac disease converges into a consensus binding solution

J Petersen, Y Kooy-Winkelaar, KL Loh, M Tran… - Structure, 2016 - cell.com
In HLA-DQ8-associated celiac disease, TRAV26-2+-TRBV9+ and TRAV8-3+-TRBV6+ T
cells recognize the immunodominant DQ8-glia-α1 epitope, whereupon a non-germline …

Determinants of gliadin-specific T cell selection in celiac disease

J Petersen, J van Bergen, KL Loh… - The Journal of …, 2015 - journals.aai.org
In HLA-DQ8–associated celiac disease (CD), the pathogenic T cell response is directed
toward an immunodominant α-gliadin–derived peptide (DQ8-glia-α1). However, our …

Increasing the X-ray diffraction power of protein crystals by dehydration: the case of bovine serum albumin and a survey of literature data

IR Krauss, F Sica, CA Mattia, A Merlino - International journal of molecular …, 2012 - mdpi.com
Serum albumin is one of the most widely studied proteins. It is the most abundant protein in
plasma with a typical concentration of 5 g/100 mL and the principal transporter of fatty acids …