Mitochondrial energetic adaptations encompass a plethora of conserved processes that
maintain cell and organismal fitness and survival in the changing environment by adjusting …

The phospholipid cardiolipin (CL) is an essential constituent of mitochondrial membranes
and plays a role in many mitochondrial processes, including respiration and energy …

Glaucoma is a leading cause of irreversible blindness worldwide and is characterized by a
slow, progressive, and multifactorial degeneration of retinal ganglion cells (RGCs) and their …

The accumulation of protein inclusions is linked to many neurodegenerative diseases that
typically develop in older individuals, due to a combination of genetic and environmental …

Mitochondria are essential organelles performing important cellular functions ranging from
bioenergetics and metabolism to apoptotic signaling and immune responses. They are …

Significance: Mitochondrial (mt) reticulum network in the cell possesses amazing
ultramorphology of parallel lamellar cristae, formed by the invaginated inner mitochondrial …

Mitochondria play central roles in cellular energetics, metabolism and signalling. Efficient
respiration, mitochondrial quality control, apoptosis and inheritance of mitochondrial DNA …

The elaborate membrane architecture of mitochondria is a prerequisite for efficient
respiration and ATP generation. The cristae membranes, invaginations of the inner …

The architecture of cristae provides a spatial mitochondrial organization that contains
functional respiratory complexes. Several protein components including OPA1 and MICOS …

Mitochondria possess two membranes of different architecture. The outer membrane
surrounds the organelle, whereas the inner membrane consists of two domains. The inner …