Glioblastoma multiforme (GBM): An overview of current therapies and mechanisms of resistance

W Wu, JL Klockow, M Zhang, F Lafortune… - Pharmacological …, 2021 - Elsevier
Glioblastoma multiforme (GBM) is a WHO grade IV glioma and the most common malignant,
primary brain tumor with a 5-year survival of 7.2%. Its highly infiltrative nature, genetic …

Glioblastoma multiforme: Pathogenesis and treatment

C Alifieris, DT Trafalis - Pharmacology & therapeutics, 2015 - Elsevier
Abstract Each year, about 5–6 cases out of 100,000 people are diagnosed with primary
malignant brain tumors, of which about 80% are malignant gliomas (MGs). Glioblastoma …

[HTML][HTML] Glioblastoma targeted therapy: updated approaches from recent biological insights

M Touat, A Idbaih, M Sanson, KL Ligon - Annals of Oncology, 2017 - Elsevier
Glioblastoma (WHO grade IV astrocytoma) is the most frequent primary brain tumor in adults,
representing a highly heterogeneous group of neoplasms that are among the most …

Pediatric high-grade glioma: biologically and clinically in need of new thinking

C Jones, MA Karajannis, DTW Jones… - Neuro …, 2017 - academic.oup.com
High-grade gliomas in children are different from those that arise in adults. Recent
collaborative molecular analyses of these rare cancers have revealed previously …

Deregulated signaling pathways in glioblastoma multiforme: molecular mechanisms and therapeutic targets

H Mao, DG LeBrun, J Yang, VF Zhu, M Li - Cancer investigation, 2012 - Taylor & Francis
Glioblastoma multiforme (GBM) is the most malignant and aggressive type of brain tumor
with an average life expectancy of less than 15 months. This is mostly due to the highly …

Current trends in targeted therapies for glioblastoma multiforme

F Ohka, A Natsume… - Neurology research …, 2012 - Wiley Online Library
Glioblastoma multiforme (GBM) is one of the most frequently occurring tumors in the central
nervous system and the most malignant tumor among gliomas. Despite aggressive …

Molecular characterizations of glioblastoma, targeted therapy, and clinical results to date

JIL Bastien, KA McNeill, HA Fine - Cancer, 2015 - Wiley Online Library
During the last decade, extensive multiplatform genome‐wide analysis has yielded a wealth
of knowledge regarding the genetic and molecular makeup of glioblastoma multiforme …

Systematic identification of non-coding pharmacogenomic landscape in cancer

Y Wang, Z Wang, J Xu, J Li, S Li, M Zhang… - Nature …, 2018 - nature.com
Emerging evidence has shown long non-coding RNAs (lncRNAs) play important roles in
cancer drug response. Here we report a lncRNA pharmacogenomic landscape by …

Small molecule tyrosine kinase inhibitors in glioblastoma

G Kim, YT Ko - Archives of pharmacal research, 2020 - Springer
Glioblastoma (GBM) is the most common malignant primary brain tumor, with poor survival
despite treatment with surgery, radiotherapy, and chemotherapy with temozolomide. Little …

Autophagic and apoptotic pathways as targets for chemotherapy in glioblastoma

C Trejo-Solís, N Serrano-Garcia… - International journal of …, 2018 - mdpi.com
Glioblastoma multiforme is the most malignant and aggressive type of brain tumor, with a
mean life expectancy of less than 15 months. This is due in part to the high resistance to …