Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have been
recognized, among the large number of non-viral vectors for gene transfection, as an …

Nucleic acid-based therapy emerges as a powerful weapon for the treatment of tumors
thanks to its direct, effective, and lasting therapeutic effect. Encouragingly, continuous …

Most studies in gene therapy are focused on developing more efficient non-viral vectors,
ignoring their stability, even though physically and chemically stable vectors are necessary …

Cholesterol is a ubiquitous molecule in biological systems, and in particular plays various
important roles in mammalian cellular processes. The presence of cholesterol is integral to …

Small interfering RNA (siRNA) has recently illustrated therapeutic potential for malignant
disorders. However, the clinical application of siRNA-based therapeutics is significantly …

Naked plasmid DNA is a powerful tool for gene therapy, but it is rapidly eliminated from the
circulation after intravenous administration. Therefore, the development of optimized DNA …

Recent advances in molecular biology combined with the culmination of the Human
Genome Project [1] have provided a genetic understanding of cellular processes and …

Multifunctional imaging nanoprobes have proven to be of great value in the research of
pathological processes, as well as the assessment of the delivery, fate, and therapeutic …

The application of gene and RNAi-based therapies to the central nervous system (CNS), for
neurological and neurodegenerative disease, offers immense potential. The issue of …

To design successful polymeric gene delivery vehicles with good biocompatibility and highly
efficient gene transfer ability is one of the great scientific challenges in modern gene …