Mitogen-activated protein kinases in innate immunity
JSC Arthur, SC Ley - Nature Reviews Immunology, 2013 - nature.com
Following pathogen infection or tissue damage, the stimulation of pattern recognition
receptors on the cell surface and in the cytoplasm of innate immune cells activates members …
receptors on the cell surface and in the cytoplasm of innate immune cells activates members …
NF-κB, the first quarter-century: remarkable progress and outstanding questions
The ability to sense and adjust to the environment is crucial to life. For multicellular
organisms, the ability to respond to external changes is essential not only for survival but …
organisms, the ability to respond to external changes is essential not only for survival but …
Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency
We report the clinical description and molecular dissection of a new fatal human inherited
disorder characterized by chronic autoinflammation, invasive bacterial infections and …
disorder characterized by chronic autoinflammation, invasive bacterial infections and …
Ubiquitination in signaling to and activation of IKK
ZJ Chen - Immunological reviews, 2012 - Wiley Online Library
A role for polyubiquitination in the activation of inhibitor of NF‐κB (IκB) kinase (IKK) through
a proteasome‐independent mechanism was first reported in 1996, but the physiological …
a proteasome‐independent mechanism was first reported in 1996, but the physiological …
Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia
Inherited, complete deficiency of human HOIL-1, a component of the linear ubiquitination
chain assembly complex (LUBAC), underlies autoinflammation, infections, and …
chain assembly complex (LUBAC), underlies autoinflammation, infections, and …
TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice
SHARPIN regulates immune signaling and contributes to full transcriptional activity and
prevention of cell death in response to TNF in vitro. The inactivating mouse Sharpin cpdm …
prevention of cell death in response to TNF in vitro. The inactivating mouse Sharpin cpdm …
HOIP deficiency causes embryonic lethality by aberrant TNFR1-mediated endothelial cell death
N Peltzer, E Rieser, L Taraborrelli, P Draber, M Darding… - Cell reports, 2014 - cell.com
Linear ubiquitination is crucial for innate and adaptive immunity. The linear ubiquitin chain
assembly complex (LUBAC), consisting of HOIL-1, HOIP, and SHARPIN, is the only known …
assembly complex (LUBAC), consisting of HOIL-1, HOIP, and SHARPIN, is the only known …
The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation
MA Rodgers, JW Bowman, H Fujita, N Orazio… - Journal of Experimental …, 2014 - rupress.org
Linear ubiquitination is a newly discovered posttranslational modification that is currently
restricted to a small number of known protein substrates. The linear ubiquitination assembly …
restricted to a small number of known protein substrates. The linear ubiquitination assembly …
The intersection of cell death and inflammasome activation
Inflammasomes sense cellular danger to activate the cysteine-aspartic protease caspase-1,
which processes precursor interleukin-1β (IL-1β) and IL-18 into their mature bioactive …
which processes precursor interleukin-1β (IL-1β) and IL-18 into their mature bioactive …
Cell death in skin function, inflammation, and disease
H Anderton, S Alqudah - Biochemical Journal, 2022 - portlandpress.com
Cell death is an essential process that plays a vital role in restoring and maintaining skin
homeostasis. It supports recovery from acute injury and infection and regulates barrier …
homeostasis. It supports recovery from acute injury and infection and regulates barrier …