Mitochondria are perhaps best known as the “powerhouse of the cell” for their role in ATP
production required for numerous cellular activities. Mitochondria have emerged as an …

Normally, the host immunological response to viral infection is coordinated to restore
homeostasis and protect the individual from possible tissue damage. The two major …

Bats host a range of disease-causing viruses without displaying clinical symptoms. The
mechanisms behind this are a continuous source of interest. Here, we studied the antiviral …

Effective responses against severe systemic infection require coordination between two
complementary defense strategies that minimize the negative impact of infection on the host …

Multiple sclerosis (MS) is a neurological disorder characterized by immune dysregulation. It
begins with a first clinical manifestation, a clinically isolated syndrome (CIS), which evolves …

Patients with sepsis differ in their clinical presentations and immune dysregulation in
response to infection, but the fundamental processes that determine this heterogeneity …

Sepsis pathobiology is complex. Heterogeneity refers to the clinical and biological variation
within sepsis cohorts. Sepsis subtypes refer to subpopulations within sepsis cohorts derived …

Pseudomonas aeruginosa is an opportunistic pathogen of great medical relevance,
although the mechanisms involved in chronic P. aeruginosa infection are unclear …

Context Atherosclerosis is a dominant cause of cardiovascular disease (CVD), including
myocardial infarction and stroke. Objective To investigate metabolic states that are …

Juruaça virus (JUAV), previously unclassified, was isolated from bats and administered to
neonatal and adult BALB/c mice to investigate acute and chronic disease progression. In …