The health benefits of exercise are well-recognized and are observed across multiple organ
systems. These beneficial effects enhance overall resilience, healthspan and longevity. The …

In mammals, the white adipocyte is a cell type that is specialized for storage of energy (in the
form of triacylglycerols) and for energy mobilization (as fatty acids). White adipocyte …

Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …

Type 2 diabetes mellitus (T2DM) is characterized by tissue-specific insulin resistance and
pancreatic β-cell dysfunction, which result from the interplay of local abnormalities within …

Linoleic acid (LA) is the most abundant polyunsaturated fatty acid found in the Western diet.
Cytochrome P450-derived LA metabolites 9, 10-epoxyoctadecenoic acid (9, 10-EpOME), 12 …

In recent years, brown adipose tissue (BAT) has been recognized not only as a main site of
non-shivering thermogenesis in mammals, but also as an endocrine organ. BAT secretes a …

Lactate is a circulating metabolite and a signalling molecule with pleiotropic physiological
effects. Studies suggest that lactate modulates energy balance by lowering food intake …

Adipose tissue is a dynamic and metabolically active organ that plays a crucial role in
energy homeostasis and endocrine function. Recent advancements in lipidomics techniques …

Lipokines are bioactive compounds, derived from adipose tissue depots, that control several
molecular signaling pathways. Recently, 12, 13-dihydroxy-9Z-octadecenoic acid (12, 13 …

The discovery and rejuvenation of metabolically active brown adipose tissue (BAT) in adult
humans have offered a new approach to treat obesity and metabolic diseases. Beyond its …