PURPOSE OF REVIEW Neurodegenerative cerebellar ataxia is a diverse collection of
diseases that are unified by gait and balance abnormalities, appendicular incoordination …

Hereditary ataxias (HA) represents an extensive group of clinically and genetically
heterogeneous neurodegenerative diseases, characterized by progressive ataxia combined …

Most cerebellar ataxias (CAs) are incurable neurological disorders, resulting in a lack of
voluntary control by inflamed or damaged cerebellum. Although CA can be either directly or …

Background The absence of effective treatments may render patients with degenerative
cerebellar ataxias susceptible to a placebo response, which could affect the outcome of …

Genetic testing strategies such as next-generation sequencing (NGS) panels and whole
genome sequencing (WGS) can be applied to the hereditary cerebellar ataxias (HCAs), but …

Background Advances in genomics provide improved opportunities for diagnosis of complex
neurogenetic disorders, yet the optimal approach to translate these benefits to the outpatient …

Abstract Calcium (Ca 2+) is a second messenger assumed to control changes in synaptic
strength in the form of both long-term depression and long-term potentiation at Purkinje cell …

Adrenoleukodystrophy (ALD) is a rare and progressive neurogenetic disease that may
manifest disparate symptoms. The present study aims at investigating the role of ataxic …

Abstract Background Primary Sjögren's syndrome (pSS) is a chronic autoimmune disorder
characterized by lymphocytic infiltrates of the exocrine glands, particularly the salivary and …

Cerebellar ataxias (CAs) are neurological diseases characterized by loss of muscle
coordination that is a result of damage and inflammation to the cerebellum. Despite …